4bd6: Difference between revisions

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-[[Image:4bd6.jpg|left|200px]]
-{{STRUCTURE_4bd6|  PDB=4bd6  |  SCENE=  }}
+==Bax domain swapped dimer in complex with BaxBH3==
+<StructureSection load='4bd6' size='340' side='right'caption='[[4bd6]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4bd6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BD6 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.494&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bd6 OCA], [https://pdbe.org/4bd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bd6 RCSB], [https://www.ebi.ac.uk/pdbsum/4bd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bd6 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref>
-===Bax domain swapped dimer in complex with BaxBH3===
+==See Also==
+*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
-{{ABSTRACT_PUBMED_23374347}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[4bd6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BD6 OCA].
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Adams, J M.]]
+[[Category: Large Structures]]
-[[Category: Colman, P M.]]
+[[Category: Adams JM]]
-[[Category: Czabotar, P E.]]
+[[Category: Colman PM]]
-[[Category: Westphal, D.]]
+[[Category: Czabotar PE]]
-[[Category: Apoptosis]]
+[[Category: Westphal D]]
-[[Category: Programmed cell death]]