4b4c: Difference between revisions

<StructureSection load='4b4c' size='340' side='right'caption='[[4b4c]], [[Resolution|resolution]] 1.62&Aring;' scene=''>

<table><tr><td colspan='2'>[[4b4c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B4C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B4C FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b4c OCA], [https://pdbe.org/4b4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b4c RCSB], [https://www.ebi.ac.uk/pdbsum/4b4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b4c ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/CHD1_HUMAN CHD1_HUMAN] ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.<ref>PMID:18042460</ref>  

 

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Allerston CK]]

[[Category: Arrowsmith CH]]

[[Category: Bountra C]]

[[Category: Burgess-Brown N]]

[[Category: Carpenter EP]]

[[Category: Cooper CDO]]

[[Category: Edwards A]]

[[Category: Gileadi O]]

[[Category: Shrestha L]]

[[Category: Vollmar M]]

[[Category: Yue WW]]

[[Category: Von Delft F]]