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==Structure of The GH47 processing alpha-1,2-mannosidase from Caulobacter strain K31 in complex with mannoimidazole==
==Structure of The GH47 processing alpha-1,2-mannosidase from Caulobacter strain K31 in complex with mannoimidazole==
<StructureSection load='4ayq' size='340' side='right' caption='[[4ayq]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
<StructureSection load='4ayq' size='340' side='right'caption='[[4ayq]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ayq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Causk Causk]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AYQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ayq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caulobacter_sp._K31 Caulobacter sp. K31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AYQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AYQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MVL:(5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL'>MVL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ayo|4ayo]], [[4ayp|4ayp]], [[4ayr|4ayr]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MVL:(5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL'>MVL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_1,2-alpha-mannosidase Mannosyl-oligosaccharide 1,2-alpha-mannosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.113 3.2.1.113] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ayq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayq OCA], [https://pdbe.org/4ayq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ayq RCSB], [https://www.ebi.ac.uk/pdbsum/4ayq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ayq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ayq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ayq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ayq RCSB], [http://www.ebi.ac.uk/pdbsum/4ayq PDBsum]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/B0SWV2_CAUSK B0SWV2_CAUSK]
Mannosides in the southern hemisphere: Conformational analysis of enzymatic mannoside hydrolysis informs strategies for enzyme inhibition and inspires solutions to mannoside synthesis. Atomic resolution structures along the reaction coordinate of an inverting alpha-mannosidase show how the enzyme distorts the substrate and transition state. QM/MM calculations reveal how the free energy landscape of isolated alpha-D-mannose is molded on enzyme to only allow one conformationally accessible reaction coordinate.
 
The reaction coordinate of a bacterial GH47 alpha-mannosidase: a combined quantum mechanical and structural approach.,Thompson AJ, Dabin J, Iglesias-Fernandez J, Ardevol A, Dinev Z, Williams SJ, Bande O, Siriwardena A, Moreland C, Hu TC, Smith DK, Gilbert HJ, Rovira C, Davies GJ Angew Chem Int Ed Engl. 2012 Oct 29;51(44):10997-1001. doi:, 10.1002/anie.201205338. Epub 2012 Sep 26. PMID:23012075<ref>PMID:23012075</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>


==See Also==
==See Also==
*[[Mannosidase|Mannosidase]]
*[[Mannosidase 3D structures|Mannosidase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Causk]]
[[Category: Caulobacter sp. K31]]
[[Category: Mannosyl-oligosaccharide 1,2-alpha-mannosidase]]
[[Category: Large Structures]]
[[Category: Dabin, J]]
[[Category: Dabin J]]
[[Category: Davies, G J]]
[[Category: Davies GJ]]
[[Category: Dinev, Z]]
[[Category: Dinev Z]]
[[Category: Gilbert, H J]]
[[Category: Gilbert HJ]]
[[Category: Hu, T C]]
[[Category: Hu TC]]
[[Category: Iglesias-Fernandez, A]]
[[Category: Iglesias-Fernandez A]]
[[Category: Iglesias-Fernandez, J]]
[[Category: Iglesias-Fernandez J]]
[[Category: Moreland, C]]
[[Category: Moreland C]]
[[Category: Rovira, C]]
[[Category: Rovira C]]
[[Category: Siriwardena, A]]
[[Category: Siriwardena A]]
[[Category: Smith, D K]]
[[Category: Smith DK]]
[[Category: Thompson, A J]]
[[Category: Thompson AJ]]
[[Category: Williams, S J]]
[[Category: Williams SJ]]
[[Category: Cazy]]
[[Category: Enzyme-carbohydrate interaction]]
[[Category: Gh47]]
[[Category: Glycosidase inhibition]]
[[Category: Glycoside hydrolase]]
[[Category: Hydrolase]]
[[Category: Mannose]]
[[Category: Quantum mechanic]]

Latest revision as of 10:16, 1 May 2024

Structure of The GH47 processing alpha-1,2-mannosidase from Caulobacter strain K31 in complex with mannoimidazoleStructure of The GH47 processing alpha-1,2-mannosidase from Caulobacter strain K31 in complex with mannoimidazole

Structural highlights

4ayq is a 1 chain structure with sequence from Caulobacter sp. K31. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.1Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

B0SWV2_CAUSK

See Also

4ayq, resolution 1.10Å

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