4a0r: Difference between revisions

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-[[Image:4a0r.png|left|200px]]
-{{STRUCTURE_4a0r|  PDB=4a0r  |  SCENE=  }}
+==Structure of bifunctional DAPA aminotransferase-DTB synthetase from Arabidopsis thaliana bound to dethiobiotin (DTB).==
+<StructureSection load='4a0r' size='340' side='right'caption='[[4a0r]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4a0r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A0R FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.68&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTB:6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC+ACID'>DTB</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0r OCA], [https://pdbe.org/4a0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a0r RCSB], [https://www.ebi.ac.uk/pdbsum/4a0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a0r ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BIODA_ARATH BIODA_ARATH] Bifunctional enzyme that catalyzes two different reactions involved in the biotin biosynthesis.  Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.  Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor.
-===Structure of bifunctional DAPA aminotransferase-DTB synthetase from Arabidopsis thaliana bound to dethiobiotin (DTB).===
+==See Also==
+*[[7%2C8-diaminopelargonic acid synthase 3D structures|7%2C8-diaminopelargonic acid synthase 3D structures]]
-{{ABSTRACT_PUBMED_22547782}}
+__TOC__
+</StructureSection>
-==About this Structure==
-[[4a0r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0R OCA].
-==Reference==
-<ref group="xtra">PMID:022547782</ref><references group="xtra"/>
 [[Category: Arabidopsis thaliana]]
-[[Category: Alban, C.]]
+[[Category: Large Structures]]
-[[Category: Cobessi, D.]]
+[[Category: Alban C]]
-[[Category: Dumas, R.]]
+[[Category: Cobessi D]]
-[[Category: Ferrer, J L.]]
+[[Category: Dumas R]]
-[[Category: Meinguet, C.]]
+[[Category: Ferrer JL]]
-[[Category: Pautre, V.]]
+[[Category: Meinguet C]]
-[[Category: Bio3-bio1]]
+[[Category: Pautre V]]
-[[Category: Biotin synthesis]]
-[[Category: Transferase]]