2xg3: Difference between revisions

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[[Image:2xg3.png|left|200px]]


{{STRUCTURE_2xg3|  PDB=2xg3  |  SCENE=  }}
==Human galectin-3 in complex with a benzamido-N-acetyllactoseamine inhibitor==
 
<StructureSection load='2xg3' size='340' side='right'caption='[[2xg3]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
===HUMAN GALECTIN-3 IN COMPLEX WITH A BENZAMIDO-N-ACETYLLACTOSEAMINE INHIBITOR===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2xg3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XG3 FirstGlance]. <br>
{{ABSTRACT_PUBMED_20873837}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UNU:BENZAMIDE'>UNU</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xg3 OCA], [https://pdbe.org/2xg3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xg3 RCSB], [https://www.ebi.ac.uk/pdbsum/2xg3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xg3 ProSAT]</span></td></tr>
[[2xg3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XG3 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>


==See Also==
==See Also==
*[[Galectin|Galectin]]
*[[Galectin 3D structures|Galectin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:020873837</ref><references group="xtra"/>
__TOC__
[[Category: Akke, M.]]
</StructureSection>
[[Category: Delaine, T.]]
[[Category: Homo sapiens]]
[[Category: Diehl, C.]]
[[Category: Large Structures]]
[[Category: Engstrom, O.]]
[[Category: Akke M]]
[[Category: Genheden, S.]]
[[Category: Delaine T]]
[[Category: Hakansson, M.]]
[[Category: Diehl C]]
[[Category: Leffler, H.]]
[[Category: Engstrom O]]
[[Category: Modig, K.]]
[[Category: Genheden S]]
[[Category: Nilsson, U.]]
[[Category: Hakansson M]]
[[Category: Ryde, U.]]
[[Category: Leffler H]]
[[Category: Ige-binding protein]]
[[Category: Modig K]]
[[Category: Lectin]]
[[Category: Nilsson U]]
[[Category: Sugar binding protein]]
[[Category: Ryde U]]

Latest revision as of 10:11, 1 May 2024

Human galectin-3 in complex with a benzamido-N-acetyllactoseamine inhibitorHuman galectin-3 in complex with a benzamido-N-acetyllactoseamine inhibitor

Structural highlights

2xg3 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.2Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LEG3_HUMAN Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.[1] [2] [3]

See Also

References

  1. ↑ Fukushi J, Makagiansar IT, Stallcup WB. NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. Mol Biol Cell. 2004 Aug;15(8):3580-90. Epub 2004 Jun 4. PMID:15181153 doi:http://dx.doi.org/10.1091/mbc.E04-03-0236
  2. ↑ Henderson NC, Sethi T. The regulation of inflammation by galectin-3. Immunol Rev. 2009 Jul;230(1):160-71. doi: 10.1111/j.1600-065X.2009.00794.x. PMID:19594635 doi:10.1111/j.1600-065X.2009.00794.x
  3. ↑ Haudek KC, Spronk KJ, Voss PG, Patterson RJ, Wang JL, Arnoys EJ. Dynamics of galectin-3 in the nucleus and cytoplasm. Biochim Biophys Acta. 2010 Feb;1800(2):181-189. Epub 2009 Jul 16. PMID:19616076 doi:S0304-4165(09)00194-9

2xg3, resolution 1.20Å

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