2v2c: Difference between revisions

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-[[Image:2v2c.png|left|200px]]
-{{STRUCTURE_2v2c|  PDB=2v2c  |  SCENE=  }}
+==The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM==
+<StructureSection load='2v2c' size='340' side='right'caption='[[2v2c]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
-===THE A178L MUTATION IN THE C-TERMINAL HINGE OF THE FLEXIBLE LOOP-6 OF TRIOSEPHOSPHATE ISOMERASE (TIM) INDUCES A MORE CLOSED CONFORMATION OF THIS HINGE REGION IN DIMERIC AND MONOMERIC TIM===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2v2c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V2C FirstGlance]. <br>
-{{ABSTRACT_PUBMED_18219118}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2c OCA], [https://pdbe.org/2v2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v2c RCSB], [https://www.ebi.ac.uk/pdbsum/2v2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2c ProSAT]</span></td></tr>
-[[2v2c]] is a 1 chain structure of [[TIM test]] and [[Triose Phosphate Isomerase]] with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2C OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TPIS_TRYBB TPIS_TRYBB]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v2c_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v2c ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[TIM test|TIM test]]
+*[[Triose phosphate isomerase 3D structures|Triose phosphate isomerase 3D structures]]
-*[[Triose Phosphate Isomerase|Triose Phosphate Isomerase]]
+__TOC__
+</StructureSection>
-==Reference==
+[[Category: Large Structures]]
-<ref group="xtra">PMID:018219118</ref><references group="xtra"/>
-[[Category: Triose-phosphate isomerase]]
 [[Category: Trypanosoma brucei brucei]]
-[[Category: Alahuhta, M.]]
+[[Category: Alahuhta M]]
-[[Category: Casteleijn, M G.]]
+[[Category: Casteleijn MG]]
-[[Category: Neubauer, P.]]
+[[Category: Neubauer P]]
-[[Category: Wierenga, R K.]]
+[[Category: Wierenga RK]]
-[[Category: 2-phospho glycollate]]
-[[Category: 2pg]]
-[[Category: A178l]]
-[[Category: Engineering]]
-[[Category: Enzyme]]
-[[Category: Fatty acid biosynthesis]]
-[[Category: Gluconeogenesis]]
-[[Category: Glycolysis]]
-[[Category: Glycosome]]
-[[Category: Hinge]]
-[[Category: Isomerase]]
-[[Category: Lipid synthesis]]
-[[Category: Loop-6]]
-[[Category: Loop6]]
-[[Category: Pentose shunt]]
-[[Category: Point mutation]]
-[[Category: Tim]]
-[[Category: Tim-barrel]]
-[[Category: Triosephosphate isomerase]]