2rol: Difference between revisions

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{{Seed}}
[[Image:2rol.jpg|left|200px]]


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==Structural Basis of PxxDY motif recognition in SH3 binding==
The line below this paragraph, containing "STRUCTURE_2rol", creates the "Structure Box" on the page.
<StructureSection load='2rol' size='340' side='right'caption='[[2rol]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2rol]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ROL FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rol OCA], [https://pdbe.org/2rol PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rol RCSB], [https://www.ebi.ac.uk/pdbsum/2rol PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rol ProSAT]</span></td></tr>
{{STRUCTURE_2rol|  PDB=2rol  |  SCENE=  }}
</table>
 
== Function ==
===Structural Basis of PxxDY motif recognition in SH3 binding===
[https://www.uniprot.org/uniprot/ES8L1_HUMAN ES8L1_HUMAN] Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.<ref>PMID:14565974</ref>  
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ro/2rol_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18644376}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
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==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rol ConSurf].
2ROL is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ROL OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:18644376</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Aitio, O.]]
[[Category: Large Structures]]
[[Category: Hellman, M.]]
[[Category: Aitio O]]
[[Category: Kesti, T.]]
[[Category: Hellman M]]
[[Category: Kleino, I.]]
[[Category: Kesti T]]
[[Category: Paakkonen, K.]]
[[Category: Kleino I]]
[[Category: Permi, P.]]
[[Category: Paakkonen K]]
[[Category: Saksela, K.]]
[[Category: Permi P]]
[[Category: Samuilova, O.]]
[[Category: Saksela K]]
[[Category: Tossavainen, H.]]
[[Category: Samuilova O]]
[[Category: Alternative splicing]]
[[Category: Tossavainen H]]
[[Category: Cd3e]]
[[Category: Coiled coil]]
[[Category: Complex structure]]
[[Category: Cytoplasm]]
[[Category: Eps8l1]]
[[Category: Immunoglobulin domain]]
[[Category: Membrane]]
[[Category: Nmr]]
[[Category: Phosphoprotein]]
[[Category: Receptor]]
[[Category: Sh3]]
[[Category: Sh3 domain]]
[[Category: Splicing/signaling protein complex]]
[[Category: Transmembrane]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar  4 14:30:54 2009''

Latest revision as of 10:05, 1 May 2024

Structural Basis of PxxDY motif recognition in SH3 bindingStructural Basis of PxxDY motif recognition in SH3 binding

Structural highlights

2rol is a 2 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ES8L1_HUMAN Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Offenhauser N, Borgonovo A, Disanza A, Romano P, Ponzanelli I, Iannolo G, Di Fiore PP, Scita G. The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway. Mol Biol Cell. 2004 Jan;15(1):91-8. Epub 2003 Oct 17. PMID:14565974 doi:http://dx.doi.org/10.1091/mbc.E03-06-0427
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