2n80: Difference between revisions

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'''Unreleased structure'''


The entry 2n80 is ON HOLD
==p75NTR DD:RhoGDI==
<StructureSection load='2n80' size='340' side='right'caption='[[2n80]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2n80]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N80 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n80 OCA], [https://pdbe.org/2n80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n80 RCSB], [https://www.ebi.ac.uk/pdbsum/2n80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n80 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TNR16_HUMAN TNR16_HUMAN] Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.<ref>PMID:14966521</ref>


Authors: lin, z., Ibanez, C.F.
==See Also==
 
*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
Description: p75NTR DD:RhoGDI
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Ibanez, C.F]]
__TOC__
[[Category: Lin, Z]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ibanez CF]]
[[Category: Lin Z]]

Latest revision as of 10:04, 1 May 2024

p75NTR DD:RhoGDIp75NTR DD:RhoGDI

Structural highlights

2n80 is a 2 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TNR16_HUMAN Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.[1]

See Also

References

  1. ↑ Mi S, Lee X, Shao Z, Thill G, Ji B, Relton J, Levesque M, Allaire N, Perrin S, Sands B, Crowell T, Cate RL, McCoy JM, Pepinsky RB. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Nat Neurosci. 2004 Mar;7(3):221-8. Epub 2004 Feb 15. PMID:14966521 doi:http://dx.doi.org/10.1038/nn1188
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