2n7q: Difference between revisions
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New page: '''Unreleased structure''' The entry 2n7q is ON HOLD Authors: Li, Y., Liew, L., Li, Q., Kang, C. Description: Structure of the transmembrane domain of human nicastrin in SDS micelles [... |
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The entry | ==Structure of the transmembrane domain of human nicastrin in SDS micelles== | ||
<StructureSection load='2n7q' size='340' side='right'caption='[[2n7q]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2n7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N7Q FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7q OCA], [https://pdbe.org/2n7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n7q RCSB], [https://www.ebi.ac.uk/pdbsum/2n7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n7q ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Hidradenitis suppurativa. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | |||
==See Also== | |||
*[[Gamma secretase|Gamma secretase]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Kang | [[Category: Homo sapiens]] | ||
[[Category: Li | [[Category: Large Structures]] | ||
[[Category: | [[Category: Kang C]] | ||
[[Category: | [[Category: Li Q]] | ||
[[Category: Li Y]] | |||
[[Category: Liew L]] | |||
Latest revision as of 10:04, 1 May 2024
Structure of the transmembrane domain of human nicastrin in SDS micellesStructure of the transmembrane domain of human nicastrin in SDS micelles
Structural highlights
DiseaseNICA_HUMAN Hidradenitis suppurativa. The disease is caused by mutations affecting the gene represented in this entry. FunctionNICA_HUMAN Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. See Also |
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