2muu: Difference between revisions

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-'''Unreleased structure'''
-The entry 2muu is ON HOLD  until Paper Publication
+==The Proteolytic Activity of Ubiquitin-specific Protease 28 Is Modulated by the N-terminal Domain==
+<StructureSection load='2muu' size='340' side='right'caption='[[2muu]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2muu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MUU FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2muu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2muu OCA], [https://pdbe.org/2muu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2muu RCSB], [https://www.ebi.ac.uk/pdbsum/2muu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2muu ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/UBP28_HUMAN UBP28_HUMAN] Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus.<ref>PMID:16901786</ref> <ref>PMID:17558397</ref> <ref>PMID:17873522</ref> <ref>PMID:18662541</ref>
-Authors: Wen, Y., Shi, L., Zhang, N.
+==See Also==
+*[[Thioesterase 3D structures|Thioesterase 3D structures]]
-Description: The Proteolytic Activity of Ubiquitin-specific Protease 28 Is Modulated by the N-terminal Domain
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Zhang, N]]
+__TOC__
-[[Category: Wen, Y]]
+</StructureSection>
-[[Category: Shi, L]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Shi L]]
+[[Category: Wen Y]]
+[[Category: Zhang N]]