2mho: Difference between revisions

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New page: '''Unreleased structure''' The entry 2mho is ON HOLD Authors: Dorr, L.A., Phelan, M.M., Lian, L. Description: NMR Solution State Structure of the PSD-95 PDZ1 -5-HT2c Complex
 
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'''Unreleased structure'''


The entry 2mho is ON HOLD
==Solution State Structure PSD-95 PDZ1 with 5HT2C Receptor peptide==
<StructureSection load='2mho' size='340' side='right'caption='[[2mho]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mho]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MHO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mho OCA], [https://pdbe.org/2mho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mho RCSB], [https://www.ebi.ac.uk/pdbsum/2mho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mho ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>


Authors: Dorr, L.A., Phelan, M.M., Lian, L.
==See Also==
 
*[[Postsynaptic density protein 3D structures|Postsynaptic density protein 3D structures]]
Description: NMR Solution State Structure of the PSD-95 PDZ1 -5-HT2c Complex
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Dorr LA]]
[[Category: Lian L]]
[[Category: Phelan MM]]

Latest revision as of 10:00, 1 May 2024

Solution State Structure PSD-95 PDZ1 with 5HT2C Receptor peptideSolution State Structure PSD-95 PDZ1 with 5HT2C Receptor peptide

Structural highlights

2mho is a 2 chain structure with sequence from Rattus norvegicus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DLG4_RAT Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.[1] [2]

See Also

References

  1. ↑ Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ. PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. J Biol Chem. 2004 Nov 5;279(45):46962-8. Epub 2004 Aug 17. PMID:15317815 doi:10.1074/jbc.M405874200
  2. ↑ Prange O, Wong TP, Gerrow K, Wang YT, El-Husseini A. A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin. Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13915-20. Epub 2004 Sep 9. PMID:15358863 doi:10.1073/pnas.0405939101
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