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==Structure of Salmonella MgtR==
==Structure of Salmonella MgtR==
<StructureSection load='2mc7' size='340' side='right' caption='[[2mc7]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='2mc7' size='340' side='right'caption='[[2mc7]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2mc7]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MC7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2mc7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MC7 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mc7 OCA], [http://pdbe.org/2mc7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mc7 RCSB], [http://www.ebi.ac.uk/pdbsum/2mc7 PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mc7 OCA], [https://pdbe.org/2mc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mc7 RCSB], [https://www.ebi.ac.uk/pdbsum/2mc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mc7 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/B0LJC7_SALTM B0LJC7_SALTM]
MgtR, a highly hydrophobic peptide expressed in Salmonella enterica serovar Typhimurium, inhibits growth in macrophages through binding to the membrane protein MgtC that has been identified as essential for replication in macrophages. While the Mycobacterium tuberculosis MgtC is highly homologous to its S. Typhi analogue, there does not appear to be an Mtb homologue for MgtR, raising significant pharmacological interest in this system. Here, solid-state NMR and EPR spectroscopy in lipid bilayer preparations were used to demonstrate the formation of a heterodimer between S. Typhi MgtR and the transmembrane helix 4 of Mtb MgtC. Based on the experimental restraints, a structural model of this heterodimer was developed using computational techniques. The result is that MgtR appears to be ideally situated in the membrane to influence the functionality of MgtC.
 
Binding of MgtR, a Salmonella Transmembrane Regulatory Peptide, to MgtC, a Mycobacterium tuberculosis Virulence Factor: A Structural Study.,Jean-Francois FL, Dai J, Yu L, Myrick A, Rubin E, Fajer PG, Song L, Zhou HX, Cross TA J Mol Biol. 2013 Oct 17. pii: S0022-2836(13)00658-X. doi:, 10.1016/j.jmb.2013.10.014. PMID:24140750<ref>PMID:24140750</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2mc7" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cross, T]]
[[Category: Large Structures]]
[[Category: Dai, J]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
[[Category: Fajer, P]]
[[Category: Cross T]]
[[Category: Jean-Francois, F]]
[[Category: Dai J]]
[[Category: Myrick, A]]
[[Category: Fajer P]]
[[Category: Rubin, E]]
[[Category: Jean-Francois F]]
[[Category: Song, L]]
[[Category: Myrick A]]
[[Category: Yu, L]]
[[Category: Rubin E]]
[[Category: Zhou, H]]
[[Category: Song L]]
[[Category: Membrane protein]]
[[Category: Yu L]]
[[Category: Transmembrane helical complex]]
[[Category: Zhou H]]

Latest revision as of 09:59, 1 May 2024

Structure of Salmonella MgtRStructure of Salmonella MgtR

Structural highlights

2mc7 is a 1 chain structure with sequence from Salmonella enterica subsp. enterica serovar Typhimurium. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solid-state NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

B0LJC7_SALTM

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