2mc5: Difference between revisions

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==A bacteriophage transcription regulator inhibits bacterial transcription initiation by -factor displacement==
==A bacteriophage transcription regulator inhibits bacterial transcription initiation by -factor displacement==
<StructureSection load='2mc5' size='340' side='right' caption='[[2mc5]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='2mc5' size='340' side='right'caption='[[2mc5]]' scene=''>
== Structural highlights ==
== Structural highlights ==
[[2mc5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Xanthomonas_campestris_phage_xp10 Xanthomonas campestris phage xp10]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC5 OCA]. <br>
<table><tr><td colspan='2'>[[2mc5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanthomonas_virus_Xp10 Xanthomonas virus Xp10]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MC5 FirstGlance]. <br>
<b>[[Related_structure|Related:]]</b> [[2mc6|2mc6]]<br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mc5 OCA], [https://pdbe.org/2mc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mc5 RCSB], [https://www.ebi.ac.uk/pdbsum/2mc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mc5 ProSAT]</span></td></tr>
<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mc5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mc5 RCSB], [http://www.ebi.ac.uk/pdbsum/2mc5 PDBsum]</span><br>
</table>
== Publication Abstract from PubMed ==
== Function ==
Bacteriophages (phages) appropriate essential processes of bacterial hosts to benefit their own development. The multisubunit bacterial RNA polymerase (RNAp) enzyme, which catalyses DNA transcription, is targeted by phage-encoded transcription regulators that selectively modulate its activity. Here, we describe the structural and mechanistic basis for the inhibition of bacterial RNAp by the transcription regulator P7 encoded by Xanthomonas oryzae phage Xp10. We reveal that P7 uses a two-step mechanism to simultaneously interact with the catalytic beta and beta' subunits of the bacterial RNAp and inhibits transcription initiation by inducing the displacement of the sigma70-factor on initial engagement of RNAp with promoter DNA. The new mode of interaction with and inhibition mechanism of bacterial RNAp by P7 underscore the remarkable variety of mechanisms evolved by phages to interfere with host transcription.
[https://www.uniprot.org/uniprot/Q8LTJ5_9CAUD Q8LTJ5_9CAUD]
 
A bacteriophage transcription regulator inhibits bacterial transcription initiation by sigma-factor displacement.,Liu B, Shadrin A, Sheppard C, Mekler V, Xu Y, Severinov K, Matthews S, Wigneshweraraj S Nucleic Acids Res. 2014 Jan 30. PMID:24482445<ref>PMID:24482445</ref>
 
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Xanthomonas campestris phage xp10]]
[[Category: Large Structures]]
[[Category: Liu, B.]]
[[Category: Xanthomonas virus Xp10]]
[[Category: Matthews, S.]]
[[Category: Liu B]]
[[Category: Severinov, K.]]
[[Category: Matthews S]]
[[Category: Shadrin, A.]]
[[Category: Severinov K]]
[[Category: Sheppard, C.]]
[[Category: Shadrin A]]
[[Category: Wigneshweraraj, S.]]
[[Category: Sheppard C]]
[[Category: Xu, Y.]]
[[Category: Wigneshweraraj S]]
[[Category: P7]]
[[Category: Xu Y]]
[[Category: Protein binding]]
[[Category: Rnap]]
[[Category: Sigma factor]]

Latest revision as of 09:59, 1 May 2024

A bacteriophage transcription regulator inhibits bacterial transcription initiation by -factor displacementA bacteriophage transcription regulator inhibits bacterial transcription initiation by -factor displacement

Structural highlights

2mc5 is a 1 chain structure with sequence from Xanthomonas virus Xp10. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q8LTJ5_9CAUD

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OCA
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