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==The solution structure of the J-domain of human DnaJA1==
==The solution structure of the J-domain of human DnaJA1==
<StructureSection load='2m6y' size='340' side='right' caption='[[2m6y]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2m6y' size='340' side='right'caption='[[2m6y]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2m6y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M6Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M6Y FirstGlance]. <br>
<table><tr><td colspan='2'>[[2m6y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M6Y FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DNAJA1, DNAJ2, HDJ2, HSJ2, HSPF4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m6y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m6y RCSB], [http://www.ebi.ac.uk/pdbsum/2m6y PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m6y OCA], [https://pdbe.org/2m6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m6y RCSB], [https://www.ebi.ac.uk/pdbsum/2m6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m6y ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DNJA1_HUMAN DNJA1_HUMAN]] Co-chaperone of Hsc70. Seems to play a role in protein import into mitochondria.  
[https://www.uniprot.org/uniprot/DNJA1_HUMAN DNJA1_HUMAN] Co-chaperone of Hsc70. Seems to play a role in protein import into mitochondria.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Pancreatic cancer has a dismal 5 year survival rate of 5.5% that has not been improved over the past 25 years despite an enormous amount of effort. Thus, there is an urgent need to identify truly novel yet druggable protein targets for drug discovery. The human protein DnaJ homologue subfamily A member 1 (DNAJA1) was previously shown to be downregulated 5-fold in pancreatic cancer cells and has been targeted as a biomarker for pancreatic cancer, but little is known about the specific biological function for DNAJA1 or the other members of the DnaJ family encoded in the human genome. Our results suggest the overexpression of DNAJA1 suppresses the stress response capabilities of the oncogenic transcription factor, c-Jun, and results in the diminution of cell survival. DNAJA1 likely activates a DnaK protein by forming a complex that suppresses the JNK pathway, the hyperphosphorylation of c-Jun, and the anti-apoptosis state found in pancreatic cancer cells. A high-quality nuclear magnetic resonance solution structure of the J-domain of DNAJA1 combined with a bioinformatics analysis and a ligand affinity screen identifies a potential DnaK binding site, which is also predicted to overlap with an inhibitory binding site, suggesting DNAJA1 activity is highly regulated.
 
Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer.,Stark JL, Mehla K, Chaika N, Acton TB, Xiao R, Singh PK, Montelione GT, Powers R Biochemistry. 2014 Mar 4;53(8):1360-72. doi: 10.1021/bi401329a. Epub 2014 Feb 19. PMID:24512202<ref>PMID:24512202</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==See Also==
</div>
*[[DnaJ homolog 3D structures|DnaJ homolog 3D structures]]
== References ==
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Acton, T B]]
[[Category: Large Structures]]
[[Category: Chaika, N]]
[[Category: Acton TB]]
[[Category: Mehla, K]]
[[Category: Chaika N]]
[[Category: Montelione, G T]]
[[Category: Mehla K]]
[[Category: Structural genomic]]
[[Category: Montelione GT]]
[[Category: Powers, R]]
[[Category: Powers R]]
[[Category: Singh, P K]]
[[Category: Singh PK]]
[[Category: Stark, J L]]
[[Category: Stark JL]]
[[Category: Xiao, R]]
[[Category: Xiao R]]
[[Category: Chaperone]]
[[Category: Protein]]

Latest revision as of 09:59, 1 May 2024

The solution structure of the J-domain of human DnaJA1The solution structure of the J-domain of human DnaJA1

Structural highlights

2m6y is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DNJA1_HUMAN Co-chaperone of Hsc70. Seems to play a role in protein import into mitochondria.

See Also

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