2ly4: Difference between revisions

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-'''Unreleased structure'''
-The entry 2ly4 is ON HOLD  until Paper Publication
+==HMGB1-facilitated p53 DNA binding occurs via HMG-box/p53 transactivation domain interaction and is regulated by the acidic tail==
+<StructureSection load='2ly4' size='340' side='right'caption='[[2ly4]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2ly4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LY4 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ly4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ly4 OCA], [https://pdbe.org/2ly4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ly4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ly4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ly4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HMGB1_HUMAN HMGB1_HUMAN] DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity).
-Authors: Rowell, J.P., Simpson, K.L., Stott, K., Watson, M., Thomas, J.O.
+==See Also==
+*[[High mobility group protein|High mobility group protein]]
-Description: HMGB1-facilitated p53 DNA binding occurs via HMG-box/p53 transactivation domain interaction and is regulated by the acidic tail
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Rowell JP]]
+[[Category: Simpson KL]]
+[[Category: Stott K]]
+[[Category: Thomas JO]]
+[[Category: Watson M]]