2l5y: Difference between revisions

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-[[Image:2l5y.png|left|200px]]
-<!--
+==NMR structure of calcium-loaded STIM2 EF-SAM.==
-The line below this paragraph, containing "STRUCTURE_2l5y", creates the "Structure Box" on the page.
+<StructureSection load='2l5y' size='340' side='right'caption='[[2l5y]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2l5y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L5Y FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-{{STRUCTURE_2l5y|  PDB=2l5y  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l5y OCA], [https://pdbe.org/2l5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l5y RCSB], [https://www.ebi.ac.uk/pdbsum/2l5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l5y ProSAT]</span></td></tr>
+</table>
-===NMR structure of calcium-loaded STIM2 EF-SAM.===
+== Function ==
+[https://www.uniprot.org/uniprot/STIM2_HUMAN STIM2_HUMAN] Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.<ref>PMID:16005298</ref> <ref>PMID:16860747</ref> <ref>PMID:17905723</ref> <ref>PMID:18160041</ref> <ref>PMID:21217057</ref> <ref>PMID:22464749</ref> <ref>PMID:23359669</ref>
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_21217057}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 21217057 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_21217057}}
-==About this Structure==
-[[2l5y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L5Y OCA].
-==Reference==
-<ref group="xtra">PMID:21217057</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Ikura, M.]]
+[[Category: Large Structures]]
-[[Category: Stathopulos, P B.]]
+[[Category: Ikura M]]
-[[Category: Zheng, L.]]
+[[Category: Stathopulos PB]]
+[[Category: Zheng L]]