2l2b: Difference between revisions

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-[[Image:2l2b.jpg|left|200px]]
-<!--
+==Structure of StnII-Y111N, a mutant of the sea anemone actinoporin Sticholysin II==
-The line below this paragraph, containing "STRUCTURE_2l2b", creates the "Structure Box" on the page.
+<StructureSection load='2l2b' size='340' side='right'caption='[[2l2b]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2l2b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L2B FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l2b OCA], [https://pdbe.org/2l2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l2b RCSB], [https://www.ebi.ac.uk/pdbsum/2l2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l2b ProSAT]</span></td></tr>
-{{STRUCTURE_2l2b|  PDB=2l2b  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ACTP2_STIHL ACTP2_STIHL] Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers. Cytolytic effects include red blood cells hemolysis, platelet aggregation and lysis, cytotoxic and cytostatic effects on fibroblasts. Lethality in mammals has been ascribed to severe vasospasm of coronary vessels, cardiac arrhythmia, and inotropic effects.<ref>PMID:10978735</ref> <ref>PMID:11478962</ref>
-===Structure of StnII-Y111N, a mutant of the sea anemone actinoporin Sticholysin II===
+==See Also==
+*[[Cytolysin 3D structures|Cytolysin 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_21481191}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 21481191 is the PubMed ID number.
+</StructureSection>
--->
+[[Category: Large Structures]]
-{{ABSTRACT_PUBMED_21481191}}
-==About this Structure==
-[[2l2b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2B OCA].
-==Reference==
-<ref group="xtra">PMID:021481191</ref><references group="xtra"/>
 [[Category: Stichodactyla helianthus]]
-[[Category: Bruix, M.]]
+[[Category: Bruix M]]
-[[Category: Pardo-Cea, M A.]]
+[[Category: Pardo-Cea MA]]
-[[Category: Santoro, J.]]
+[[Category: Santoro J]]
-[[Category: Actinoporin sticholysin variant]]
-[[Category: Pore forming toxin]]
-[[Category: Toxin]]