2l0f: Difference between revisions

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-{{Seed}}
-[[Image:2l0f.jpg|left|200px]]
-<!--
+==Solution NMR structure of human polymerase iota UBM2 (P692A mutant) in complex with ubiquitin==
-The line below this paragraph, containing "STRUCTURE_2l0f", creates the "Structure Box" on the page.
+<StructureSection load='2l0f' size='340' side='right'caption='[[2l0f]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2l0f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L0F FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0f OCA], [https://pdbe.org/2l0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l0f RCSB], [https://www.ebi.ac.uk/pdbsum/2l0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l0f ProSAT]</span></td></tr>
-{{STRUCTURE_2l0f|  PDB=2l0f  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RS27A_HUMAN RS27A_HUMAN] Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.<ref>PMID:16543144</ref> <ref>PMID:19754430</ref>   Ribosomal protein S27a is a component of the 40S subunit of the ribosome.<ref>PMID:16543144</ref> <ref>PMID:19754430</ref>
-===Solution NMR structure of human polymerase iota UBM2 (P692A mutant) in complex with ubiquitin===
+==See Also==
+*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
+*[[3D structures of ubiquitin|3D structures of ubiquitin]]
-==About this Structure==
+== References ==
-L0F is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0F OCA].
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Benirschke, R.]]
+[[Category: Large Structures]]
-[[Category: Cui, G.]]
+[[Category: Benirschke R]]
-[[Category: Mer, G.]]
+[[Category: Cui G]]
-[[Category: Dna polymerase iota]]
+[[Category: Mer G]]
-[[Category: Isopeptide bond]]
-[[Category: Nucleus]]
-[[Category: Phosphoprotein]]
-[[Category: Protein binding]]
-[[Category: Translesion dna synthesis]]
-[[Category: Ubiquitin-binding motif]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov  3 11:04:32 2010''