2l0a: Difference between revisions

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 ==Solution NMR Structure of Signal transducing adapter molecule 1 STAM-1 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4479E==
-<StructureSection load='2l0a' size='340' side='right' caption='[[2l0a]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='2l0a' size='340' side='right'caption='[[2l0a]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2l0a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L0A FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2l0a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L0A FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STAM, STAM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l0a RCSB], [http://www.ebi.ac.uk/pdbsum/2l0a PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0a OCA], [https://pdbe.org/2l0a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l0a RCSB], [https://www.ebi.ac.uk/pdbsum/2l0a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l0a ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/STAM1_HUMAN STAM1_HUMAN]] Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
+[https://www.uniprot.org/uniprot/STAM1_HUMAN STAM1_HUMAN] Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/2l0a_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/2l0a_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2l0a ConSurf].
 <div style="clear:both"></div>
 __TOC__
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Acton, T B]]
+[[Category: Large Structures]]
-[[Category: Ciccosanti, C]]
+[[Category: Acton TB]]
-[[Category: Everett, J K]]
+[[Category: Ciccosanti C]]
-[[Category: Janjua, H]]
+[[Category: Everett JK]]
-[[Category: Montelione, G T]]
+[[Category: Janjua H]]
-[[Category: Structural genomic]]
+[[Category: Montelione GT]]
-[[Category: Rost, B]]
+[[Category: Rost B]]
-[[Category: Shastry, R]]
+[[Category: Shastry R]]
-[[Category: Tang, Y]]
+[[Category: Tang Y]]
-[[Category: Xiao, R]]
+[[Category: Xiao R]]
-[[Category: PSI, Protein structure initiative]]
-[[Category: Signaling protein]]