2l0a: Difference between revisions

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-[[Image:2l0a.png|left|200px]]
-{{STRUCTURE_2l0a|  PDB=2l0a  |  SCENE=  }}
+==Solution NMR Structure of Signal transducing adapter molecule 1 STAM-1 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4479E==
+<StructureSection load='2l0a' size='340' side='right'caption='[[2l0a]]' scene=''>
-===Solution NMR Structure of Signal transducing adapter molecule 1 STAM-1 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4479E===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2l0a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L0A FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0a OCA], [https://pdbe.org/2l0a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l0a RCSB], [https://www.ebi.ac.uk/pdbsum/2l0a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l0a ProSAT]</span></td></tr>
-[[2l0a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0A OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/STAM1_HUMAN STAM1_HUMAN] Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/2l0a_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2l0a ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Acton, T B.]]
+[[Category: Large Structures]]
-[[Category: Ciccosanti, C.]]
+[[Category: Acton TB]]
-[[Category: Everett, J K.]]
+[[Category: Ciccosanti C]]
-[[Category: Janjua, H.]]
+[[Category: Everett JK]]
-[[Category: Montelione, G T.]]
+[[Category: Janjua H]]
-[[Category: NESG, Northeast Structural Genomics Consortium.]]
+[[Category: Montelione GT]]
-[[Category: Rost, B.]]
+[[Category: Rost B]]
-[[Category: Shastry, R.]]
+[[Category: Shastry R]]
-[[Category: Tang, Y.]]
+[[Category: Tang Y]]
-[[Category: Xiao, R.]]
+[[Category: Xiao R]]
-[[Category: Protein structure initiative]]
-[[Category: Psi-2]]
-[[Category: Signaling protein]]
-[[Category: Structural genomic]]