2ky6: Difference between revisions
New page: '''Unreleased structure''' The entry 2ky6 is ON HOLD Authors: Milbradt, A.G., Sun, Z.J., Selenko, P., Takeuchi, K., Naar, A.M., Wagner, G. Description: ''Page seeded by [http://oca.w... |
No edit summary |
||
| (11 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
The entry | ==Structure of ARC92VBD/MED25ACID== | ||
<StructureSection load='2ky6' size='340' side='right'caption='[[2ky6]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2ky6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KY6 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ky6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ky6 OCA], [https://pdbe.org/2ky6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ky6 RCSB], [https://www.ebi.ac.uk/pdbsum/2ky6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ky6 ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/MED25_HUMAN MED25_HUMAN] Charcot-Marie-Tooth disease type 2B2. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:19290556</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MED25_HUMAN MED25_HUMAN] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription.<ref>PMID:14657022</ref> <ref>PMID:14983011</ref> <ref>PMID:17641689</ref> | |||
==See Also== | |||
*[[Mediator|Mediator]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Milbradt AG]] | |||
[[Category: Naar AM]] | |||
[[Category: Selenko P]] | |||
[[Category: Sun ZJ]] | |||
[[Category: Takeuchi K]] | |||
[[Category: Wagner G]] | |||