2kug: Difference between revisions

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-{{STRUCTURE_2kug|  PDB=2kug  |  SCENE=  }}
-===Halothane binds to druggable sites in calcium-calmodulin: Solution Structure of halothane-CaM N-terminal domain===
-==About this Structure==
+==Halothane binds to druggable sites in calcium-calmodulin: Solution Structure of halothane-CaM N-terminal domain==
-[[2kug]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KUG OCA].
+<StructureSection load='2kug' size='340' side='right'caption='[[2kug]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2kug]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KUG FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HLT:2-BROMO-2-CHLORO-1,1,1-TRIFLUOROETHANE'>HLT</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kug OCA], [https://pdbe.org/2kug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kug RCSB], [https://www.ebi.ac.uk/pdbsum/2kug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kug ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4.  The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
+== Function ==
+[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ku/2kug_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kug ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Calmodulin|Calmodulin]]
+*[[Calmodulin 3D structures|Calmodulin 3D structures]]
-[[Category: Human]]
+== References ==
-[[Category: Hock, T J.]]
+<references/>
-[[Category: Jones, K A.]]
+__TOC__
-[[Category: Juranic, N.]]
+</StructureSection>
-[[Category: Macura, S.]]
+[[Category: Homo sapiens]]
-[[Category: Penheiter, A R.]]
+[[Category: Large Structures]]
-[[Category: Simeonov, M V.]]
+[[Category: Hock TJ]]
-[[Category: Streiff, J H.]]
+[[Category: Jones KA]]
-[[Category: Calcium binding]]
+[[Category: Juranic N]]
-[[Category: Calmodulin]]
+[[Category: Macura S]]
-[[Category: Cytoskeleton]]
+[[Category: Penheiter AR]]
-[[Category: Halothane]]
+[[Category: Simeonov MV]]
-[[Category: Isopeptide bond]]
+[[Category: Streiff JH]]
-[[Category: Metal binding protein]]
-[[Category: Methylation]]
-[[Category: Phosphoprotein]]
-[[Category: Volatile anesthetic]]