2kro: Difference between revisions

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New page: '''Unreleased structure''' The entry 2kro is ON HOLD Authors: Ortega Roldan, J., Azuaga, A.I., van Nuland, N.A.J., Blackledge, M. Description: RDC refined high resolution structure of ...
 
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'''Unreleased structure'''


The entry 2kro is ON HOLD
==RDC refined high resolution structure of the third SH3 domain of CD2AP==
<StructureSection load='2kro' size='340' side='right'caption='[[2kro]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2kro]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KRO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kro OCA], [https://pdbe.org/2kro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kro RCSB], [https://www.ebi.ac.uk/pdbsum/2kro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kro ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CD2AP_MOUSE CD2AP_MOUSE] Required for cytokinesis (By similarity). Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus.<ref>PMID:10514378</ref>


Authors: Ortega Roldan, J., Azuaga, A.I., van Nuland, N.A.J., Blackledge, M.
==See Also==
 
*[[CD2-associated protein 3D structures|CD2-associated protein 3D structures]]
Description: RDC refined high resolution structure of the third SH3 domain of CD2AP
== References ==
 
<references/>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 30 13:41:51 2009''
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Azuaga AI]]
[[Category: Blackledge M]]
[[Category: Ortega Roldan J]]
[[Category: Van Nuland NAJ]]

Latest revision as of 09:48, 1 May 2024

RDC refined high resolution structure of the third SH3 domain of CD2APRDC refined high resolution structure of the third SH3 domain of CD2AP

Structural highlights

2kro is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CD2AP_MOUSE Required for cytokinesis (By similarity). Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus.[1]

See Also

References

  1. ↑ Shih NY, Li J, Karpitskii V, Nguyen A, Dustin ML, Kanagawa O, Miner JH, Shaw AS. Congenital nephrotic syndrome in mice lacking CD2-associated protein. Science. 1999 Oct 8;286(5438):312-5. PMID:10514378
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