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==Solution structure of MAST205-PDZ complexed with the C-terminus of a rabies virus G protein== | ==Solution structure of MAST205-PDZ complexed with the C-terminus of a rabies virus G protein== | ||
<StructureSection load='2kqf' size='340' side='right' caption='[[2kqf | <StructureSection load='2kqf' size='340' side='right'caption='[[2kqf]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2kqf]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2kqf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rabies_lyssavirus Rabies lyssavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KQF FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqf OCA], [https://pdbe.org/2kqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kqf RCSB], [https://www.ebi.ac.uk/pdbsum/2kqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kqf ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/MAST2_HUMAN MAST2_HUMAN] Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity).[UniProtKB:Q60592] | ||
==See Also== | ==See Also== | ||
*[[Serine/threonine protein kinase|Serine/threonine protein kinase]] | *[[Microtubule-associated serine/threonine kinase|Microtubule-associated serine/threonine kinase]] | ||
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bernard | [[Category: Large Structures]] | ||
[[Category: Cordier | [[Category: Rabies lyssavirus]] | ||
[[Category: Delepierre | [[Category: Bernard A]] | ||
[[Category: Lafon | [[Category: Cordier F]] | ||
[[Category: Simenel | [[Category: Delepierre M]] | ||
[[Category: Terrien | [[Category: Lafon M]] | ||
[[Category: Wolff | [[Category: Simenel C]] | ||
[[Category: Terrien E]] | |||
[[Category: Wolff N]] | |||
Latest revision as of 09:47, 1 May 2024
Solution structure of MAST205-PDZ complexed with the C-terminus of a rabies virus G proteinSolution structure of MAST205-PDZ complexed with the C-terminus of a rabies virus G protein
Structural highlights
FunctionMAST2_HUMAN Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity).[UniProtKB:Q60592] See Also |
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