2khn: Difference between revisions

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-{{Seed}}
-[[Image:2khn.jpg|left|200px]]
-<!--
+==NMR solution structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646E.==
-The line below this paragraph, containing "STRUCTURE_2khn", creates the "Structure Box" on the page.
+<StructureSection load='2khn' size='340' side='right'caption='[[2khn]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2khn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KHN FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2khn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2khn OCA], [https://pdbe.org/2khn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2khn RCSB], [https://www.ebi.ac.uk/pdbsum/2khn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2khn ProSAT], [https://www.topsan.org/Proteins/NESGC/2khn TOPSAN]</span></td></tr>
-{{STRUCTURE_2khn|  PDB=2khn  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kh/2khn_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2khn ConSurf].
+<div style="clear:both"></div>
-===NMR solution structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646E.===
+==See Also==
+*[[Intersectin|Intersectin]]
+== References ==
-==About this Structure==
+<references/>
-KHN is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KHN OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Acton, T B.]]
+[[Category: Large Structures]]
-[[Category: Everett, J K.]]
+[[Category: Acton TB]]
-[[Category: Foote, E L.]]
+[[Category: Everett JK]]
-[[Category: Garcia, E.]]
+[[Category: Foote EL]]
-[[Category: Ghosh, A.]]
+[[Category: Garcia E]]
-[[Category: Janjua, H.]]
+[[Category: Ghosh A]]
-[[Category: Mills, J L.]]
+[[Category: Janjua H]]
-[[Category: Montelione, G T.]]
+[[Category: Mills JL]]
-[[Category: NESG, Northeast Structural Genomics Consortium.]]
+[[Category: Montelione GT]]
-[[Category: Shastry, R.]]
+[[Category: Shastry R]]
-[[Category: Szyperski, T.]]
+[[Category: Szyperski T]]
-[[Category: Xiao, R.]]
+[[Category: Xiao R]]
-[[Category: Zhang, Q.]]
+[[Category: Zhang Q]]
-[[Category: Alternative splicing]]
-[[Category: Calcium]]
-[[Category: Cell junction]]
-[[Category: Cell projection]]
-[[Category: Coiled coil]]
-[[Category: Endocytosis]]
-[[Category: Gft nmr]]
-[[Category: High throughput]]
-[[Category: Human intersectin-1]]
-[[Category: Membrane]]
-[[Category: Nesgc]]
-[[Category: Nmr]]
-[[Category: Northeast structural genomics consortium]]
-[[Category: Phosphoprotein]]
-[[Category: Protein structure initiative]]
-[[Category: Psi-2]]
-[[Category: Sh3 domain]]
-[[Category: Signaling protein]]
-[[Category: Structural genomic]]
-[[Category: Synapse]]
-[[Category: Synaptosome]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 22 11:23:17 2009''