2khn: Difference between revisions

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 ==NMR solution structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646E.==
-<StructureSection load='2khn' size='340' side='right'caption='[[2khn]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='2khn' size='340' side='right'caption='[[2khn]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2khn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KHN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KHN FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2khn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KHN FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ITSN1, ITSN, SH3D1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2khn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2khn OCA], [http://pdbe.org/2khn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2khn RCSB], [http://www.ebi.ac.uk/pdbsum/2khn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2khn ProSAT], [http://www.topsan.org/Proteins/NESGC/2khn TOPSAN]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2khn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2khn OCA], [https://pdbe.org/2khn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2khn RCSB], [https://www.ebi.ac.uk/pdbsum/2khn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2khn ProSAT], [https://www.topsan.org/Proteins/NESGC/2khn TOPSAN]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>
+[https://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
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 </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2khn ConSurf].
 <div style="clear:both"></div>
+==See Also==
+*[[Intersectin|Intersectin]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Acton, T B]]
+[[Category: Acton TB]]
-[[Category: Everett, J K]]
+[[Category: Everett JK]]
-[[Category: Foote, E L]]
+[[Category: Foote EL]]
-[[Category: Garcia, E]]
+[[Category: Garcia E]]
-[[Category: Ghosh, A]]
+[[Category: Ghosh A]]
-[[Category: Janjua, H]]
+[[Category: Janjua H]]
-[[Category: Mills, J L]]
+[[Category: Mills JL]]
-[[Category: Montelione, G T]]
+[[Category: Montelione GT]]
-[[Category: Structural genomic]]
+[[Category: Shastry R]]
-[[Category: Shastry, R]]
+[[Category: Szyperski T]]
-[[Category: Szyperski, T]]
+[[Category: Xiao R]]
-[[Category: Xiao, R]]
+[[Category: Zhang Q]]
-[[Category: Zhang, Q]]
-[[Category: Alternative splicing]]
-[[Category: Calcium]]
-[[Category: Cell junction]]
-[[Category: Cell projection]]
-[[Category: Coiled coil]]
-[[Category: Endocytosis]]
-[[Category: Gft nmr]]
-[[Category: High throughput]]
-[[Category: Human intersectin-1]]
-[[Category: Membrane]]
-[[Category: Nesgc]]
-[[Category: Phosphoprotein]]
-[[Category: PSI, Protein structure initiative]]
-[[Category: Sh3 domain]]
-[[Category: Signaling protein]]
-[[Category: Synapse]]
-[[Category: Synaptosome]]