2kg7: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2kg7.png|left|200px]]
-<!--
+==Structure and features of the complex formed by the tuberculosis virulence factors Rv0287 and Rv0288==
-The line below this paragraph, containing "STRUCTURE_2kg7", creates the "Structure Box" on the page.
+<StructureSection load='2kg7' size='340' side='right'caption='[[2kg7]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2kg7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KG7 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kg7 OCA], [https://pdbe.org/2kg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kg7 RCSB], [https://www.ebi.ac.uk/pdbsum/2kg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kg7 ProSAT]</span></td></tr>
-{{STRUCTURE_2kg7|  PDB=2kg7  |  SCENE=  }}
+</table>
+== Function ==
-===Structure and features of the complex formed by the tuberculosis virulence factors Rv0287 and Rv0288===
+[https://www.uniprot.org/uniprot/ESXG_MYCTU ESXG_MYCTU] EsxG, in complex with EsxH, disrupts ESCRT function and impairs host phagosome maturation, thereby promoting intracellular bacterial growth. The complex acts by interacting, via EsxH, with the host hepatocyte growth factor-regulated tyrosine kinase substrate (HGS/HRS), a component of the ESCRT machinery. EsxG stabilizes EsxH in the host cytosol.<ref>PMID:24204276</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-==About this Structure==
+Check<jmol>
-[[2kg7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KG7 OCA].
+  <jmolCheckbox>
-[[Category: Mycobacterium tuberculosis]]
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/2kg7_consurf.spt"</scriptWhenChecked>
-[[Category: Carr, M D.]]
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-[[Category: Ilghari, D.]]
+    <text>to colour the structure by Evolutionary Conservation</text>
-[[Category: Kirsty, L L.]]
+  </jmolCheckbox>
-[[Category: Philip, R S.]]
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kg7 ConSurf].
-[[Category: Veverka, V L.]]
+<div style="clear:both"></div>
-[[Category: Waters, L C.]]
+== References ==
-[[Category: Protein complex]]
+<references/>
-[[Category: Unknown function]]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mycobacterium tuberculosis H37Rv]]
+[[Category: Carr MD]]
+[[Category: Ilghari D]]
+[[Category: Kirsty LL]]
+[[Category: Philip RS]]
+[[Category: Veverka VL]]
+[[Category: Waters LC]]