2kax: Difference between revisions

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[[Image:2kax.png|left|200px]]


{{STRUCTURE_2kax| PDB=2kax | SCENE= }}
==Solution structure and dynamics of S100A5 in the apo and Ca2+ -bound states==
<StructureSection load='2kax' size='340' side='right'caption='[[2kax]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2kax]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KAX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KAX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kax OCA], [https://pdbe.org/2kax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kax RCSB], [https://www.ebi.ac.uk/pdbsum/2kax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kax ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/S10A5_HUMAN S10A5_HUMAN] Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.<ref>PMID:10882717</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ka/2kax_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kax ConSurf].
<div style="clear:both"></div>


===Solution structure and dynamics of S100A5 in the apo and Ca2+ -bound states===
==See Also==
 
*[[S100 proteins 3D structures|S100 proteins 3D structures]]
{{ABSTRACT_PUBMED_19536568}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[2kax]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KAX OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:019536568</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bertini, I.]]
[[Category: Large Structures]]
[[Category: Gupta, S Das.]]
[[Category: Bertini I]]
[[Category: Hu, X.]]
[[Category: Das Gupta S]]
[[Category: Karavelas, T.]]
[[Category: Hu X]]
[[Category: Luchinat, C.]]
[[Category: Karavelas T]]
[[Category: Parigi, G.]]
[[Category: Luchinat C]]
[[Category: SPINE, Structural Proteomics in Europe.]]
[[Category: Parigi G]]
[[Category: Yuan, J.]]
[[Category: Yuan J]]
[[Category: Calcium binding protien]]
[[Category: Ef-hand]]
[[Category: Metal binding protein]]
[[Category: S100a5]]
[[Category: Spine]]
[[Category: Spine2]]
[[Category: Structural genomic]]
[[Category: Structural proteomics in europe]]

Latest revision as of 09:44, 1 May 2024

Solution structure and dynamics of S100A5 in the apo and Ca2+ -bound statesSolution structure and dynamics of S100A5 in the apo and Ca2+ -bound states

Structural highlights

2kax is a 2 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

S10A5_HUMAN Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Schafer BW, Fritschy JM, Murmann P, Troxler H, Durussel I, Heizmann CW, Cox JA. Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding protein of the EF-hand superfamily. J Biol Chem. 2000 Sep 29;275(39):30623-30. PMID:10882717 doi:http://dx.doi.org/10.1074/jbc.M002260200
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