2k86: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:2k86.png|left|200px]]
-<!--
+==Solution Structure of FOXO3a Forkhead domain==
-The line below this paragraph, containing "STRUCTURE_2k86", creates the "Structure Box" on the page.
+<StructureSection load='2k86' size='340' side='right'caption='[[2k86]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2k86]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K86 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K86 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k86 OCA], [https://pdbe.org/2k86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k86 RCSB], [https://www.ebi.ac.uk/pdbsum/2k86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k86 ProSAT]</span></td></tr>
-{{STRUCTURE_2k86|  PDB=2k86  |  SCENE=  }}
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/FOXO3_HUMAN FOXO3_HUMAN] Note=A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. Translocation t(6;11)(q21;q23) with MLL/HRX.
+== Function ==
+[https://www.uniprot.org/uniprot/FOXO3_HUMAN FOXO3_HUMAN] Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.<ref>PMID:10102273</ref> <ref>PMID:16751106</ref> <ref>PMID:21329882</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k8/2k86_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k86 ConSurf].
+<div style="clear:both"></div>
-===Solution Structure of FOXO3a Forkhead domain===
+==See Also==
+*[[FOX 3D structures|FOX 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_18824006}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 18824006 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_18824006}}
-==About this Structure==
-K86 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K86 OCA].
-==Reference==
-Biochemical and Structural Characterization of an Intramolecular Interaction in FOXO3a and Its Binding with p53., Wang F, Marshall CB, Yamamoto K, Li GY, Plevin MJ, You H, Mak TW, Ikura M, J Mol Biol. 2008 Sep 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18824006 18824006]
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Ikura, M.]]
+[[Category: Ikura M]]
-[[Category: Li, G.]]
+[[Category: Li G]]
-[[Category: Marshall, C B.]]
+[[Category: Marshall CB]]
-[[Category: Plevin, M J.]]
+[[Category: Plevin MJ]]
-[[Category: Wang, F.]]
+[[Category: Wang F]]
-[[Category: Activator]]
-[[Category: Apoptosis]]
-[[Category: Chromosomal rearrangement]]
-[[Category: Cytoplasm]]
-[[Category: Dna binding domain]]
-[[Category: Dna binding protein]]
-[[Category: Dna-binding]]
-[[Category: Forkhead]]
-[[Category: Nucleus]]
-[[Category: Phosphoprotein]]
-[[Category: Proto-oncogene]]
-[[Category: Transcription]]
-[[Category: Transcription regulation]]
-[[Category: Winged-helix]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 26 20:35:02 2008''