2k3r: Difference between revisions

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[[Image:2k3r.png|left|200px]]


{{STRUCTURE_2k3r|  PDB=2k3r  |  SCENE=  }}
==Pfu Rpp21 structure and assignments==
 
<StructureSection load='2k3r' size='340' side='right'caption='[[2k3r]]' scene=''>
===Pfu Rpp21 structure and assignments===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2k3r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K3R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K3R FirstGlance]. <br>
{{ABSTRACT_PUBMED_18922021}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k3r OCA], [https://pdbe.org/2k3r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k3r RCSB], [https://www.ebi.ac.uk/pdbsum/2k3r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k3r ProSAT]</span></td></tr>
[[2k3r]] is a 1 chain structure of [[Ribonuclease]] with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K3R OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/RNP4_PYRFU RNP4_PYRFU] Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. The RNA is catalytic, but its KM for pre-tRNA is 170-fold decreased in the presence of the 4 known protein subunits (Rnp1-4). The protein subunits also decrease the amount of Mg(2+) needed for activity.<ref>PMID:17053064</ref> <ref>PMID:21683084</ref> <ref>PMID:22298511</ref>


==See Also==
==See Also==
*[[Ribonuclease|Ribonuclease]]
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:018922021</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
[[Category: Ribonuclease P]]
[[Category: Amero CD]]
[[Category: Amero, C D.]]
[[Category: Boomershine WP]]
[[Category: Boomershine, W P.]]
[[Category: Foster MP]]
[[Category: Foster, M P.]]
[[Category: Xu Y]]
[[Category: Xu, Y.]]
[[Category: Hydrolase]]
[[Category: Pfu rpp21]]
[[Category: Rnase p]]
[[Category: Trna processing]]

Latest revision as of 09:43, 1 May 2024

Pfu Rpp21 structure and assignmentsPfu Rpp21 structure and assignments

Structural highlights

2k3r is a 1 chain structure with sequence from Pyrococcus furiosus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RNP4_PYRFU Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. The RNA is catalytic, but its KM for pre-tRNA is 170-fold decreased in the presence of the 4 known protein subunits (Rnp1-4). The protein subunits also decrease the amount of Mg(2+) needed for activity.[1] [2] [3]

See Also

References

  1. ↑ Tsai HY, Pulukkunat DK, Woznick WK, Gopalan V. Functional reconstitution and characterization of Pyrococcus furiosus RNase P. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16147-52. Epub 2006 Oct 19. PMID:17053064 doi:http://dx.doi.org/10.1073/pnas.0608000103
  2. ↑ Chen WY, Xu Y, Cho IM, Oruganti SV, Foster MP, Gopalan V. Cooperative RNP assembly: complementary rescue of structural defects by protein and RNA subunits of archaeal RNase P. J Mol Biol. 2011 Aug 12;411(2):368-83. doi: 10.1016/j.jmb.2011.05.012. Epub 2011 , Jun 12. PMID:21683084 doi:http://dx.doi.org/10.1016/j.jmb.2011.05.012
  3. ↑ Chen WY, Singh D, Lai LB, Stiffler MA, Lai HD, Foster MP, Gopalan V. Fidelity of tRNA 5'-maturation: a possible basis for the functional dependence of archaeal and eukaryal RNase P on multiple protein cofactors. Nucleic Acids Res. 2012 May;40(10):4666-80. doi: 10.1093/nar/gks013. Epub 2012, Jan 31. PMID:22298511 doi:http://dx.doi.org/10.1093/nar/gks013
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