2k2j: Difference between revisions

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-{{Seed}}
-[[Image:2k2j.png|left|200px]]
-<!--
+==NMR solution structure of the split PH domain from Phospholipase C gamma 2==
-The line below this paragraph, containing "STRUCTURE_2k2j", creates the "Structure Box" on the page.
+<StructureSection load='2k2j' size='340' side='right'caption='[[2k2j]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2k2j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K2J FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2j OCA], [https://pdbe.org/2k2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k2j RCSB], [https://www.ebi.ac.uk/pdbsum/2k2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k2j ProSAT]</span></td></tr>
-{{STRUCTURE_2k2j|  PDB=2k2j  |  SCENE=  }}
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PLCG2_HUMAN PLCG2_HUMAN] Defects in PLCG2 are the cause of familial cold autoinflammatory syndrome type 3 (FCAS3) [MIM:[https://omim.org/entry/614468 614468]. An autosomal dominant immune disorder characterized by the development of cutaneous urticaria, erythema, and pruritis in response to cold exposure. Affected individuals have variable additional immunologic defects, including antibody deficiency, decreased numbers of B cells, defective B cells, increased susceptibility to infection, and increased risk of autoimmune disorders.<ref>PMID:22236196</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/PLCG2_HUMAN PLCG2_HUMAN] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/2k2j_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k2j ConSurf].
+<div style="clear:both"></div>
-===NMR solution structure of the split PH domain from Phospholipase C gamma 2===
+==See Also==
+*[[Phospholipase C|Phospholipase C]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_18728011}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 18728011 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_18728011}}
-==About this Structure==
-K2J is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2J OCA].
-==Reference==
-Rac Regulates Its Effector Phospholipase C{gamma}2 through Interaction with a Split Pleckstrin Homology Domain., Walliser C, Retlich M, Harris R, Everett KL, Josephs MB, Vatter P, Esposito D, Driscoll PC, Katan M, Gierschik P, Bunney TD, J Biol Chem. 2008 Oct 31;283(44):30351-62. Epub 2008 Aug 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18728011 18728011]
 [[Category: Homo sapiens]]
-[[Category: Phosphoinositide phospholipase C]]
+[[Category: Large Structures]]
-[[Category: Bunney, T D.]]
+[[Category: Bunney TD]]
-[[Category: Driscoll, P C.]]
+[[Category: Driscoll PC]]
-[[Category: Harris, R.]]
+[[Category: Harris R]]
-[[Category: Katan, M.]]
+[[Category: Katan M]]
-[[Category: C-terminal helix]]
-[[Category: Calcium]]
-[[Category: Hydrolase]]
-[[Category: Lipid degradation]]
-[[Category: Phosphoprotein]]
-[[Category: Polymorphism]]
-[[Category: Sh2 domain]]
-[[Category: Sh3 domain]]
-[[Category: Signaling protein]]
-[[Category: Transducer]]
-[[Category: Two sheeted beta barrel]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 20 07:51:54 2008''