2k2j: Difference between revisions

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-[[Image:2k2j.png|left|200px]]
-{{STRUCTURE_2k2j|  PDB=2k2j  |  SCENE=  }}
+==NMR solution structure of the split PH domain from Phospholipase C gamma 2==
+<StructureSection load='2k2j' size='340' side='right'caption='[[2k2j]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2k2j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K2J FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2j OCA], [https://pdbe.org/2k2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k2j RCSB], [https://www.ebi.ac.uk/pdbsum/2k2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k2j ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PLCG2_HUMAN PLCG2_HUMAN] Defects in PLCG2 are the cause of familial cold autoinflammatory syndrome type 3 (FCAS3) [MIM:[https://omim.org/entry/614468 614468]. An autosomal dominant immune disorder characterized by the development of cutaneous urticaria, erythema, and pruritis in response to cold exposure. Affected individuals have variable additional immunologic defects, including antibody deficiency, decreased numbers of B cells, defective B cells, increased susceptibility to infection, and increased risk of autoimmune disorders.<ref>PMID:22236196</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/PLCG2_HUMAN PLCG2_HUMAN] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/2k2j_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k2j ConSurf].
+<div style="clear:both"></div>
-===NMR solution structure of the split PH domain from Phospholipase C gamma 2===
+==See Also==
+*[[Phospholipase C|Phospholipase C]]
-{{ABSTRACT_PUBMED_18728011}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[2k2j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K2J OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:018728011</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Phosphoinositide phospholipase C]]
+[[Category: Large Structures]]
-[[Category: Bunney, T D.]]
+[[Category: Bunney TD]]
-[[Category: Driscoll, P C.]]
+[[Category: Driscoll PC]]
-[[Category: Harris, R.]]
+[[Category: Harris R]]
-[[Category: Katan, M.]]
+[[Category: Katan M]]
-[[Category: C-terminal helix]]
-[[Category: Hydrolase]]
-[[Category: Lipid degradation]]
-[[Category: Phosphoprotein]]
-[[Category: Sh2 domain]]
-[[Category: Sh3 domain]]
-[[Category: Signaling protein]]
-[[Category: Transducer]]
-[[Category: Two sheeted beta barrel]]