2jxx: Difference between revisions

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[[Image:2jxx.jpg|left|200px]]


<!--
==NMR solution structure of Ubiquitin-like domain of NFATC2IP. Northeast Structural Genomics Consortium target HR5627==
The line below this paragraph, containing "STRUCTURE_2jxx", creates the "Structure Box" on the page.
<StructureSection load='2jxx' size='340' side='right'caption='[[2jxx]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2jxx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JXX FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxx OCA], [https://pdbe.org/2jxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jxx RCSB], [https://www.ebi.ac.uk/pdbsum/2jxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxx ProSAT], [https://www.topsan.org/Proteins/NESGC/2jxx TOPSAN]</span></td></tr>
{{STRUCTURE_2jxx|  PDB=2jxx  |  SCENE= }}
</table>
 
== Function ==
'''NMR solution structure of Ubiquitin-like domain of NFATC2IP. Northeast Structural Genomics Consortium target HR5627'''
[https://www.uniprot.org/uniprot/NF2IP_HUMAN NF2IP_HUMAN] In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
2JXX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXX OCA].  
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jxx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jxx ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Butler, C.]]
[[Category: Butler C]]
[[Category: Dhe-Paganon, S.]]
[[Category: Dhe-Paganon S]]
[[Category: Doherty, R S.]]
[[Category: Doherty RS]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Fares, C.]]
[[Category: Fares C]]
[[Category: Karra, M.]]
[[Category: Karra M]]
[[Category: Lemak, A.]]
[[Category: Lemak A]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Srisailam S]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Weigelt J]]
[[Category: Srisailam, S.]]
[[Category: Yee A]]
[[Category: Weigelt, J.]]
[[Category: Yee, A.]]
[[Category: Alternative splicing]]
[[Category: Coiled coil]]
[[Category: Cytoplasmic 2-interacting protein]]
[[Category: Methylation]]
[[Category: Nesg]]
[[Category: Nfat complex]]
[[Category: Northeast structural genomics consortium]]
[[Category: Nuclear factor of activated t-cell]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Protein binding]]
[[Category: Protein structure initiative]]
[[Category: Psi-2]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Ubiquitin like homologue]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:23:23 2008''

Latest revision as of 09:43, 1 May 2024

NMR solution structure of Ubiquitin-like domain of NFATC2IP. Northeast Structural Genomics Consortium target HR5627NMR solution structure of Ubiquitin-like domain of NFATC2IP. Northeast Structural Genomics Consortium target HR5627

Structural highlights

2jxx is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

NF2IP_HUMAN In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Drag the structure with the mouse to rotate

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