2jxx: Difference between revisions
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==NMR solution structure of Ubiquitin-like domain of NFATC2IP. Northeast Structural Genomics Consortium target HR5627== | ==NMR solution structure of Ubiquitin-like domain of NFATC2IP. Northeast Structural Genomics Consortium target HR5627== | ||
<StructureSection load='2jxx' size='340' side='right'caption='[[2jxx | <StructureSection load='2jxx' size='340' side='right'caption='[[2jxx]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2jxx]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2jxx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JXX FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxx OCA], [https://pdbe.org/2jxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jxx RCSB], [https://www.ebi.ac.uk/pdbsum/2jxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxx ProSAT], [https://www.topsan.org/Proteins/NESGC/2jxx TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/NF2IP_HUMAN NF2IP_HUMAN] In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Butler | [[Category: Butler C]] | ||
[[Category: Dhe-Paganon | [[Category: Dhe-Paganon S]] | ||
[[Category: Doherty | [[Category: Doherty RS]] | ||
[[Category: Edwards | [[Category: Edwards AM]] | ||
[[Category: Fares | [[Category: Fares C]] | ||
[[Category: Karra | [[Category: Karra M]] | ||
[[Category: Lemak | [[Category: Lemak A]] | ||
[[Category: Srisailam S]] | |||
[[Category: Srisailam | [[Category: Weigelt J]] | ||
[[Category: Weigelt | [[Category: Yee A]] | ||
[[Category: Yee | |||