2j4l: Difference between revisions

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-[[Image:2j4l.jpg|left|200px]]<br /><applet load="2j4l" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2j4l, resolution 2.80&Aring;" />
-'''CRYSTAL STRUCTURE OF URIDYLATE KINASE FROM SULFOLOBUS SOLFATARICUS IN COMPLEX WITH UTP TO 2.8 ANGSTROM RESOLUTION'''<br />
-==About this Structure==
+==Crystal structure of uridylate kinase from Sulfolobus solfataricus in complex with UTP to 2.8 Angstrom resolution==
-J4L is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=UTP:'>UTP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/UMP_kinase UMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.22 2.7.4.22] Known structural/functional Site: <scene name='pdbsite=AC1:Utp+Binding+Site+For+Chain+L'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4L OCA].
+<StructureSection load='2j4l' size='340' side='right'caption='[[2j4l]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-[[Category: Single protein]]
+== Structural highlights ==
-[[Category: Sulfolobus solfataricus]]
+<table><tr><td colspan='2'>[[2j4l]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J4L FirstGlance]. <br>
-[[Category: UMP kinase]]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-[[Category: Jensen, K F.]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UTP:URIDINE+5-TRIPHOSPHATE'>UTP</scene></td></tr>
-[[Category: Jensen, K S.]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4l OCA], [https://pdbe.org/2j4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j4l RCSB], [https://www.ebi.ac.uk/pdbsum/2j4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j4l ProSAT]</span></td></tr>
-[[Category: Johansson, E.]]
+</table>
-[[Category: MG]]
+== Function ==
-[[Category: UTP]]
+[https://www.uniprot.org/uniprot/PYRH_SACS2 PYRH_SACS2] Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor. Is also able to phosphorylate dUMP, although much less efficiently.<ref>PMID:17297917</ref>
-[[Category: aspartokinase fold]]
+== Evolutionary Conservation ==
-[[Category: nucleoside monophosphate kinase]]
+[[Image:Consurf_key_small.gif|200px|right]]
-[[Category: pyrimidine nucleotide synthesis]]
+Check<jmol>
-[[Category: transferase]]
+  <jmolCheckbox>
-[[Category: ump kinase]]
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j4/2j4l_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j4l ConSurf].
+<div style="clear:both"></div>
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:59:07 2008''
+==See Also==
+*[[Uridylate kinase|Uridylate kinase]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Saccharolobus solfataricus]]
+[[Category: Jensen KF]]
+[[Category: Jensen KS]]
+[[Category: Johansson E]]