2j4k: Difference between revisions

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-[[Image:2j4k.jpg|left|200px]]
- {{Structure
+==Crystal structure of uridylate kinase from Sulfolobus solfataricus in complex with UMP to 2.2 Angstrom resolution==
-|PDB= 2j4k |SIZE=350|CAPTION= <scene name='initialview01'>2j4k</scene>, resolution 2.20&Aring;
+<StructureSection load='2j4k' size='340' side='right'caption='[[2j4k]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-|SITE= <scene name='pdbsite=AC1:Cd+Binding+Site+For+Chain+F'>AC1</scene>
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=U5P:URIDINE-5'-MONOPHOSPHATE'>U5P</scene>
+<table><tr><td colspan='2'>[[2j4k]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J4K FirstGlance]. <br>
-|ACTIVITY= [http://en.wikipedia.org/wiki/UMP_kinase UMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.22 2.7.4.22]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j4k OCA], [https://pdbe.org/2j4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j4k RCSB], [https://www.ebi.ac.uk/pdbsum/2j4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j4k ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PYRH_SACS2 PYRH_SACS2] Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor. Is also able to phosphorylate dUMP, although much less efficiently.<ref>PMID:17297917</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j4/2j4k_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j4k ConSurf].
+<div style="clear:both"></div>
-'''CRYSTAL STRUCTURE OF URIDYLATE KINASE FROM SULFOLOBUS SOLFATARICUS IN COMPLEX WITH UMP TO 2.2 ANGSTROM RESOLUTION'''
+==See Also==
+*[[Uridylate kinase|Uridylate kinase]]
+== References ==
-==About this Structure==
+<references/>
-J4K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J4K OCA].
+__TOC__
-[[Category: Single protein]]
+</StructureSection>
-[[Category: Sulfolobus solfataricus]]
+[[Category: Large Structures]]
-[[Category: UMP kinase]]
+[[Category: Saccharolobus solfataricus P2]]
-[[Category: Jensen, K F.]]
+[[Category: Jensen KF]]
-[[Category: Jensen, K S.]]
+[[Category: Jensen KS]]
-[[Category: Johansson, E.]]
+[[Category: Johansson E]]
-[[Category: CD]]
-[[Category: MG]]
-[[Category: U5P]]
-[[Category: aspartokinase family]]
-[[Category: kinase]]
-[[Category: nucleoside monophosphate kinase]]
-[[Category: pyrimidine biosynthesis]]
-[[Category: pyrimidine nucleotide synthesis]]
-[[Category: transferase]]
-[[Category: ump kinase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:37:06 2008''