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[[Image:2glw.gif|left|200px]]<br /><applet load="2glw" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2glw" />
'''The solution structure of PHS018 from pyrococcus horikoshii'''<br />


==Overview==
==The solution structure of PHS018 from pyrococcus horikoshii==
The core of swapped-hairpin and double-psi beta barrels is formed by duplication of a conserved betaalphabeta element, suggesting a common evolutionary origin. The path connecting the two folds is unclear as the two barrels are not interconvertible by a simple topological modification, such as circular permutation. We have identified a protein family whose sequence properties are intermediate to the two folds. The structure of one of these proteins, Pyrococcus horikoshii PhS018, is also built by duplication of the conserved betaalphabeta element but shows yet a third topology, which we name the RIFT barrel. This topology is widespread in the structure database and spans three folds of the SCOP classification, including the middle domain of EF-Tu and the N domain of F1-ATPase. We propose that swapped-hairpin beta barrels arose from an ancestral RIFT barrel by strand invasion and double-psi beta barrels by a strand swap. We group the three barrel types into a metafold, the cradle-loop barrels.
<StructureSection load='2glw' size='340' side='right'caption='[[2glw]]' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2glw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GLW FirstGlance]. <br>
2GLW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GLW OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2glw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2glw OCA], [https://pdbe.org/2glw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2glw RCSB], [https://www.ebi.ac.uk/pdbsum/2glw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2glw ProSAT]</span></td></tr>
==Reference==
</table>
Common evolutionary origin of swapped-hairpin and double-psi beta barrels., Coles M, Hulko M, Djuranovic S, Truffault V, Koretke K, Martin J, Lupas AN, Structure. 2006 Oct;14(10):1489-98. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17027498 17027498]
== Function ==
[[Category: Pyrococcus horikoshii]]
[https://www.uniprot.org/uniprot/O73971_PYRHO O73971_PYRHO]  
[[Category: Single protein]]
== Evolutionary Conservation ==
[[Category: Coles, M.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Hulko, M.]]
Check<jmol>
[[Category: Lupas, A N.]]
  <jmolCheckbox>
[[Category: Martin, J.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gl/2glw_consurf.spt"</scriptWhenChecked>
[[Category: Truffault, V.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: bioinformatics]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: nmr]]
  </jmolCheckbox>
[[Category: rift barrel]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2glw ConSurf].
 
<div style="clear:both"></div>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:32:57 2008''
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pyrococcus horikoshii OT3]]
[[Category: Coles M]]
[[Category: Hulko M]]
[[Category: Lupas AN]]
[[Category: Martin J]]
[[Category: Truffault V]]

Latest revision as of 09:40, 1 May 2024

The solution structure of PHS018 from pyrococcus horikoshiiThe solution structure of PHS018 from pyrococcus horikoshii

Structural highlights

2glw is a 1 chain structure with sequence from Pyrococcus horikoshii OT3. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

O73971_PYRHO

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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