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| [[Image:2ezs.gif|left|200px]]
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| <!-- | | ==SOLUTION NMR STRUCTURE OF ECTODOMAIN OF SIV GP41, MODELS 31-40 OF AN ENSEMBLE OF 40 SIMULATED ANNEALING STRUCTURES== |
| The line below this paragraph, containing "STRUCTURE_2ezs", creates the "Structure Box" on the page.
| | <StructureSection load='2ezs' size='340' side='right'caption='[[2ezs]]' scene=''> |
| You may change the PDB parameter (which sets the PDB file loaded into the applet) | | == Structural highlights == |
| or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
| | <table><tr><td colspan='2'>[[2ezs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EZS FirstGlance]. <br> |
| or leave the SCENE parameter empty for the default display.
| | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| -->
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ezs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ezs OCA], [https://pdbe.org/2ezs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ezs RCSB], [https://www.ebi.ac.uk/pdbsum/2ezs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ezs ProSAT]</span></td></tr> |
| {{STRUCTURE_2ezs| PDB=2ezs | SCENE= }}
| | </table> |
| | == Function == |
| | [https://www.uniprot.org/uniprot/Q88031_SIV Q88031_SIV] |
| | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] |
| | Check<jmol> |
| | <jmolCheckbox> |
| | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ez/2ezs_consurf.spt"</scriptWhenChecked> |
| | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| | <text>to colour the structure by Evolutionary Conservation</text> |
| | </jmolCheckbox> |
| | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ezs ConSurf]. |
| | <div style="clear:both"></div> |
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| '''SOLUTION NMR STRUCTURE OF ECTODOMAIN OF SIV GP41, MODELS 31-40 OF AN ENSEMBLE OF 40 SIMULATED ANNEALING STRUCTURES'''
| | ==See Also== |
| | | *[[Gp41 3D Structures|Gp41 3D Structures]] |
| | | __TOC__ |
| ==Overview==
| | </StructureSection> |
| The solution structure of the ectodomain of simian immunodeficiency virus (SIV) gp41 (e-gp41), consisting of residues 27-149, has been determined by multidimensional heteronuclear NMR spectroscopy. SIV e-gp41 is a symmetric 44 kDa trimer with each subunit consisting of antiparallel N-terminal (residues 30-80) and C-terminal (residues 107-147) helices connected by a 26 residue loop (residues 81-106). The N-terminal helices of each subunit form a parallel coiled-coil structure in the interior of the complex which is surrounded by the C-terminal helices located on the exterior of the complex. The loop region is ordered and displays numerous intermolecular and non-sequential intramolecular contacts. The helical core of SIV e-gp41 is similar to recent X-ray structures of truncated constructs of the helical core of HIV-1 e-gp41. The present structure establishes unambiguously the connectivity of the N- and C-terminal helices in the trimer, and characterizes the conformation of the intervening loop, which has been implicated by mutagenesis and antibody epitope mapping to play a key role in gp120 association. In conjunction with previous studies, the solution structure of the SIV e-gp41 ectodomain provides insight into the binding site of gp120 and the mechanism of cell fusion. The present structure of SIV e-gp41 represents one of the largest protein structures determined by NMR to date.
| | [[Category: Large Structures]] |
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| ==About this Structure==
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| 2EZS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EZS OCA].
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| ==Reference==
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| Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41., Caffrey M, Cai M, Kaufman J, Stahl SJ, Wingfield PT, Covell DG, Gronenborn AM, Clore GM, EMBO J. 1998 Aug 17;17(16):4572-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9707417 9707417]
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| [[Category: Simian immunodeficiency virus]] | | [[Category: Simian immunodeficiency virus]] |
| [[Category: Single protein]]
| | [[Category: Caffrey M]] |
| [[Category: Caffrey, M.]] | | [[Category: Clore GM]] |
| [[Category: Clore, G M.]] | | [[Category: Gronenborn AM]] |
| [[Category: Gronenborn, A M.]] | |
| [[Category: Siv gp41 ectodomain]]
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| [[Category: Virus envelope protein]]
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| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:17:39 2008''
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