2arw: Difference between revisions

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-{{Seed}}
-[[Image:2arw.png|left|200px]]
-<!--
+==The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor==
-The line below this paragraph, containing "STRUCTURE_2arw", creates the "Structure Box" on the page.
+<StructureSection load='2arw' size='340' side='right'caption='[[2arw]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2arw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ARW FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2arw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2arw OCA], [https://pdbe.org/2arw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2arw RCSB], [https://www.ebi.ac.uk/pdbsum/2arw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2arw ProSAT]</span></td></tr>
-{{STRUCTURE_2arw|  PDB=2arw  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IL6RA_HUMAN IL6RA_HUMAN] Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.<ref>PMID:11017875</ref> <ref>PMID:16270750</ref>   Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.<ref>PMID:11017875</ref> <ref>PMID:16270750</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ar/2arw_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2arw ConSurf].
+<div style="clear:both"></div>
-===The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor===
+==See Also==
+*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_16972794}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 16972794 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_16972794}}
-==About this Structure==
-ARW is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ARW OCA].
-==Reference==
-<ref group="xtra">PMID:16972794</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Dingley, A J.]]
+[[Category: Large Structures]]
-[[Category: Grotzinger, J.]]
+[[Category: Dingley AJ]]
-[[Category: Hecht, O.]]
+[[Category: Grotzinger J]]
-[[Category: Ozbek, S.]]
+[[Category: Hecht O]]
-[[Category: Rose-John, S.]]
+[[Category: Ozbek S]]
-[[Category: Schwantner, A.]]
+[[Category: Rose-John S]]
-[[Category: Cytokine]]
+[[Category: Schwantner A]]
-[[Category: Fibronectin-type iii like]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 22 10:48:19 2009''