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| [[Image:1ztn.gif|left|200px]]
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| {{Structure
| | ==INACTIVATION GATE OF POTASSIUM CHANNEL RAW3, NMR, 8 STRUCTURES== |
| |PDB= 1ztn |SIZE=350|CAPTION= <scene name='initialview01'>1ztn</scene>
| | <StructureSection load='1ztn' size='340' side='right'caption='[[1ztn]]' scene=''> |
| |SITE= | | == Structural highlights == |
| |LIGAND=
| | <table><tr><td colspan='2'>[[1ztn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZTN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZTN FirstGlance]. <br> |
| |ACTIVITY=
| | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| |GENE=
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ztn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ztn OCA], [https://pdbe.org/1ztn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ztn RCSB], [https://www.ebi.ac.uk/pdbsum/1ztn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ztn ProSAT]</span></td></tr> |
| }}
| | </table> |
| | == Function == |
| | [https://www.uniprot.org/uniprot/KCNC4_HUMAN KCNC4_HUMAN] This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. |
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| '''INACTIVATION GATE OF POTASSIUM CHANNEL RAW3, NMR, 8 STRUCTURES'''
| | ==See Also== |
| | | *[[Potassium channel 3D structures|Potassium channel 3D structures]] |
| | | __TOC__ |
| ==Overview== | | </StructureSection> |
| The electrical signalling properties of neurons originate largely from the gating properties of their ion channels. N-type inactivation of voltage-gated potassium (Kv) channels is the best-understood gating transition in ion channels, and occurs by a 'ball-and-chain' type mechanism. In this mechanism an N-terminal domain (inactivation gate), which is tethered to the cytoplasmic side of the channel protein by a protease-cleavable chain, binds to its receptor at the inner vestibule of the channel, thereby physically blocking the pore. Even when synthesized as a peptide, ball domains restore inactivation in Kv channels whose inactivation domains have been deleted. Using high-resolution nuclear magnetic resonance (NMR) spectroscopy, we analysed the three-dimensional structure of the ball peptides from two rapidly inactivating mammalian K. channels (Raw3 (Kv3.4) and RCK4 (Kv1.4)). The inactivation peptide of Raw3 (Raw3-IP) has a compact structure that exposes two phosphorylation sites and allows the formation of an intramolecular disulphide bridge between two spatially close cysteine residues. Raw3-IP exhibits a characteristic surface charge pattern with a positively charged, a hydrophobic, and a negatively charged region. The RCK4 inactivation peptide (RCK4-IP) shows a similar spatial distribution of charged and uncharged regions, but is more flexible and less ordered in its amino-terminal part.
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| ==About this Structure==
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| 1ZTN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZTN OCA].
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| ==Reference==
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| NMR structure of inactivation gates from mammalian voltage-dependent potassium channels., Antz C, Geyer M, Fakler B, Schott MK, Guy HR, Frank R, Ruppersberg JP, Kalbitzer HR, Nature. 1997 Jan 16;385(6613):272-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9000078 9000078]
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| [[Category: Homo sapiens]] | | [[Category: Homo sapiens]] |
| [[Category: Single protein]] | | [[Category: Large Structures]] |
| [[Category: Antz, C.]] | | [[Category: Antz C]] |
| [[Category: Fakler, B.]] | | [[Category: Fakler B]] |
| [[Category: Frank, R.]] | | [[Category: Frank R]] |
| [[Category: Geyer, M.]] | | [[Category: Geyer M]] |
| [[Category: Guy, H R.]] | | [[Category: Guy HR]] |
| [[Category: Kalbitzer, H R.]] | | [[Category: Kalbitzer HR]] |
| [[Category: Ruppersberg, J P.]] | | [[Category: Ruppersberg JP]] |
| [[Category: Schott, M.]] | | [[Category: Schott M]] |
| [[Category: inactivation gate]]
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| [[Category: nmr]]
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| [[Category: potassium channel]]
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| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:39:42 2008''
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