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[[Image:1e9w.png|left|200px]]


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==Structure of the macrocycle thiostrepton solved using the anomalous dispersive contribution from sulfur==
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<StructureSection load='1e9w' size='340' side='right'caption='[[1e9w]], [[Resolution|resolution]] 1.02&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1e9w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_azureus Streptomyces azureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E9W FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.02&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BB9:(2Z)-2-AMINO-3-SULFANYLPROP-2-ENOIC+ACID'>BB9</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=MH6:3-HYDROXY-2-IMINOPROPANOIC+ACID'>MH6</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PRD_000223:THIOSTREPTON'>PRD_000223</scene>, <scene name='pdbligand=QUA:8-HYDROXY-4-(1-HYDROXYETHYL)QUINOLINE-2-CARBOXYLIC+ACID'>QUA</scene>, <scene name='pdbligand=TS9:(2S,3S,4R)-2-AMINO-3,4-DIHYDROXY-3-METHYLPENTANOIC+ACID'>TS9</scene></td></tr>
{{STRUCTURE_1e9w|  PDB=1e9w  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e9w OCA], [https://pdbe.org/1e9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e9w RCSB], [https://www.ebi.ac.uk/pdbsum/1e9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e9w ProSAT]</span></td></tr>
 
</table>
===STRUCTURE OF THE MACROCYCLE THIOSTREPTON SOLVED USING THE ANOMALOUS DISPERSIVE CONTRIBUTION FROM SULFUR===
== Function ==
 
[https://www.uniprot.org/uniprot/THCL_STRAJ THCL_STRAJ] Has bacteriocidal activity. Inhibits bacterial protein biosynthesis by acting on the elongation factor Tu (EF-Tu) (By similarity).
 
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_11320328}}
 
==About this Structure==
1E9W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_azureus Streptomyces azureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E9W OCA].  
 
==Reference==
Structure of the macrocycle thiostrepton solved using the anomalous dispersion contribution of sulfur., Bond CS, Shaw MP, Alphey MS, Hunter WN, Acta Crystallogr D Biol Crystallogr. 2001 May;57(Pt 5):755-8. Epub 2001, Apr 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11320328 11320328]
[[Category: Single protein]]
[[Category: Streptomyces azureus]]
[[Category: Streptomyces azureus]]
[[Category: Alphey, M S.]]
[[Category: Alphey MS]]
[[Category: Bond, C S.]]
[[Category: Bond CS]]
[[Category: Hunter, W N.]]
[[Category: Hunter WN]]
[[Category: Shaw, M P.]]
[[Category: Shaw MP]]
[[Category: Antibiotic]]
[[Category: Ribosome]]
[[Category: Thioazole]]
[[Category: Translation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 00:22:58 2008''

Latest revision as of 09:27, 1 May 2024

Structure of the macrocycle thiostrepton solved using the anomalous dispersive contribution from sulfurStructure of the macrocycle thiostrepton solved using the anomalous dispersive contribution from sulfur

Structural highlights

1e9w is a 1 chain structure with sequence from Streptomyces azureus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.02Å
Ligands:, , , , , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

THCL_STRAJ Has bacteriocidal activity. Inhibits bacterial protein biosynthesis by acting on the elongation factor Tu (EF-Tu) (By similarity).

1e9w, resolution 1.02Å

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