1r0s: Difference between revisions

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-[[Image:1r0s.png|left|200px]]
-{{STRUCTURE_1r0s|  PDB=1r0s  |  SCENE=  }}
+==Crystal structure of ADP-ribosyl cyclase Glu179Ala mutant==
+<StructureSection load='1r0s' size='340' side='right'caption='[[1r0s]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-===Crystal structure of ADP-ribosyl cyclase Glu179Ala mutant===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1r0s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R0S FirstGlance]. <br>
-{{ABSTRACT_PUBMED_15016363}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r0s OCA], [https://pdbe.org/1r0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r0s RCSB], [https://www.ebi.ac.uk/pdbsum/1r0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r0s ProSAT]</span></td></tr>
-==About this Structure==
+</table>
-[[1r0s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R0S OCA].
+== Function ==
+[https://www.uniprot.org/uniprot/NADA_APLCA NADA_APLCA] Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for calcium mobilization from endoplasmic reticulum. Also has cADPr hydrolase activity.<ref>PMID:11829748</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r0/1r0s_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r0s ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[ADP-ribosyl cyclase|ADP-ribosyl cyclase]]
+*[[Cluster of Differentiation CD38|Cluster of Differentiation CD38]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:015016363</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Aplysia californica]]
-[[Category: Graeff, R.]]
+[[Category: Large Structures]]
-[[Category: Hao, Q.]]
+[[Category: Graeff R]]
-[[Category: Kriksunov, I A.]]
+[[Category: Hao Q]]
-[[Category: Lee, H C.]]
+[[Category: Kriksunov IA]]
-[[Category: Love, M L.]]
+[[Category: Lee HC]]
-[[Category: Munshi, C.]]
+[[Category: Love ML]]
-[[Category: Szebenyi, D M.E.]]
+[[Category: Munshi C]]
-[[Category: Thiel, D J.]]
+[[Category: Szebenyi DME]]
-[[Category: Adp-ribosyl cyclase]]
+[[Category: Thiel DJ]]
-[[Category: Ca2+ signalling]]
-[[Category: Cyclic adp-ribose]]
-[[Category: Hydrolase]]
-[[Category: Naadp]]