1r0s: Difference between revisions

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[[Image:1r0s.png|left|200px]]


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==Crystal structure of ADP-ribosyl cyclase Glu179Ala mutant==
The line below this paragraph, containing "STRUCTURE_1r0s", creates the "Structure Box" on the page.
<StructureSection load='1r0s' size='340' side='right'caption='[[1r0s]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1r0s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R0S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r0s OCA], [https://pdbe.org/1r0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r0s RCSB], [https://www.ebi.ac.uk/pdbsum/1r0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r0s ProSAT]</span></td></tr>
{{STRUCTURE_1r0s|  PDB=1r0s  |  SCENE=  }}
</table>
 
== Function ==
===Crystal structure of ADP-ribosyl cyclase Glu179Ala mutant===
[https://www.uniprot.org/uniprot/NADA_APLCA NADA_APLCA] Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for calcium mobilization from endoplasmic reticulum. Also has cADPr hydrolase activity.<ref>PMID:11829748</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r0s ConSurf].
[[1r0s]] is a 2 chain structure of [[ADP-ribosyl cyclase]] with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R0S OCA].  
<div style="clear:both"></div>


==See Also==
==See Also==
*[[ADP-ribosyl cyclase]]
*[[Cluster of Differentiation CD38|Cluster of Differentiation CD38]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:15016363</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Aplysia californica]]
[[Category: Aplysia californica]]
[[Category: Graeff, R.]]
[[Category: Large Structures]]
[[Category: Hao, Q.]]
[[Category: Graeff R]]
[[Category: Kriksunov, I A.]]
[[Category: Hao Q]]
[[Category: Lee, H C.]]
[[Category: Kriksunov IA]]
[[Category: Love, M L.]]
[[Category: Lee HC]]
[[Category: Munshi, C.]]
[[Category: Love ML]]
[[Category: Szebenyi, D M.E.]]
[[Category: Munshi C]]
[[Category: Thiel, D J.]]
[[Category: Szebenyi DME]]
[[Category: Adp-ribosyl cyclase]]
[[Category: Thiel DJ]]
[[Category: Ca2+ signalling]]
[[Category: Cyclic adp-ribose]]
[[Category: Hydrolase]]
[[Category: Naadp]]
[[Category: X-ray crystallography]]

Latest revision as of 09:08, 17 April 2024

Crystal structure of ADP-ribosyl cyclase Glu179Ala mutantCrystal structure of ADP-ribosyl cyclase Glu179Ala mutant

Structural highlights

1r0s is a 2 chain structure with sequence from Aplysia californica. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NADA_APLCA Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for calcium mobilization from endoplasmic reticulum. Also has cADPr hydrolase activity.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Chini EN, Chini CC, Kato I, Takasawa S, Okamoto H. CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues. Biochem J. 2002 Feb 15;362(Pt 1):125-30. PMID:11829748

1r0s, resolution 2.00Å

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OCA
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