1qnq: Difference between revisions

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-[[Image:1qnq.png|left|200px]]
-{{STRUCTURE_1qnq|  PDB=1qnq  |  SCENE=  }}
+==The 3-D structure of a Trichoderma reesei b-mannanase from glycoside hydrolase family 5==
+<StructureSection load='1qnq' size='340' side='right'caption='[[1qnq]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1qnq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trichoderma_reesei Trichoderma reesei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QNQ FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TPT:2,2 6,2-TERPYRIDINE+PLATINUM(II)+CHLORIDE'>TPT</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnq OCA], [https://pdbe.org/1qnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qnq RCSB], [https://www.ebi.ac.uk/pdbsum/1qnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qnq ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MANA_HYPJR MANA_HYPJR] Endo-1,4-mannanase that catalyzes the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans and heteromannans. It is a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans. Active against locust bean gum and ivory nut mannan, releasing mainly tri- and disaccharides (PubMed:7793911, Ref.3, Ref.4, PubMed:8529653). Also has transglycosylation activity. Transglycosylation of two mannotrioses into a mannohexaose is the major transglycosylation route (PubMed:8529653, Ref.7, PubMed:24950755).<ref>PMID:24950755</ref> <ref>PMID:7793911</ref> <ref>PMID:8529653</ref> [PROSITE-ProRule:PRU00597][SAM:MobiDB-lite]<ref>PMID:24950755</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qn/1qnq_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qnq ConSurf].
+<div style="clear:both"></div>
-===THE 3-D STRUCTURE OF A TRICHODERMA REESEI B-MANNANASE FROM GLYCOSIDE HYDROLASE FAMILY 5===
+==See Also==
+*[[Mannosidase 3D structures|Mannosidase 3D structures]]
-{{ABSTRACT_PUBMED_10666621}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[1qnq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trichoderma_reesei Trichoderma reesei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNQ OCA].
+</StructureSection>
+[[Category: Large Structures]]
-==Reference==
-<ref group="xtra">PMID:010666621</ref><references group="xtra"/>
-[[Category: Mannan endo-1,4-beta-mannosidase]]
-[[Category: Trichoderma reesei]]
-[[Category: Murshudov, G.]]
-[[Category: Penttila, M.]]
-[[Category: Sabini, E.]]
-[[Category: Schubert, H.]]
-[[Category: Siika-Aho, M.]]
-[[Category: Wilson, K S.]]
-[[Category: Anomalous scattering]]
-[[Category: Hydrolase]]
-[[Category: Mannanase]]
 [[Category: Trichoderma reesei]]
+[[Category: Murshudov G]]
+[[Category: Penttila M]]
+[[Category: Sabini E]]
+[[Category: Schubert H]]
+[[Category: Siika-Aho M]]
+[[Category: Wilson KS]]