1ql7: Difference between revisions

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[[Image:1ql7.jpg|left|200px]]


{{Structure
==FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN==
|PDB= 1ql7 |SIZE=350|CAPTION= <scene name='initialview01'>1ql7</scene>, resolution 2.1&Aring;
<StructureSection load='1ql7' size='340' side='right'caption='[[1ql7]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Zen+Binding+Site+For+Chain+A'>AC3</scene> and <scene name='pdbsite=ACT:Active+Site'>ACT</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=ZEN:[4-(6-CHLORO-NAPHTHALENE-2-SULFONYL)-PIPERAZIN-1-YL]- (3,4,5,6-TETRAHYDRO-2H-[1,4&#39;]BIPYRIDINYL-4-YL)- METHANONE'>ZEN</scene>
<table><tr><td colspan='2'>[[1ql7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QL7 FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZEN:[4-(6-CHLORO-NAPHTHALENE-2-SULFONYL)-PIPERAZIN-1-YL]-+(3,4,5,6-TETRAHYDRO-2H-[1,4]BIPYRIDINYL-4-YL)-+METHANONE'>ZEN</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ql7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ql7 OCA], [https://pdbe.org/1ql7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ql7 RCSB], [https://www.ebi.ac.uk/pdbsum/1ql7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ql7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRY1_BOVIN TRY1_BOVIN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ql/1ql7_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ql7 ConSurf].
<div style="clear:both"></div>


'''FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN'''
==See Also==
 
*[[Trypsin 3D structures|Trypsin 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
1QL7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QL7 OCA].
 
==Reference==
pH-dependent binding modes observed in trypsin crystals: lessons for structure-based drug design., Stubbs MT, Reyda S, Dullweber F, Moller M, Klebe G, Dorsch D, Mederski WW, Wurziger H, Chembiochem. 2002 Mar 1;3(2-3):246-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11921406 11921406]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Trypsin]]
[[Category: Stubbs MT]]
[[Category: Stubbs, M T.]]
[[Category: CA]]
[[Category: SO4]]
[[Category: ZEN]]
[[Category: hydrolase]]
[[Category: serine proteinase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 13:21:35 2008''

Latest revision as of 09:04, 17 April 2024

FACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSINFACTOR XA SPECIFIC INHIBITOR IN COMPLEX WITH BOVINE TRYPSIN

Structural highlights

1ql7 is a 1 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TRY1_BOVIN

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1ql7, resolution 2.10Å

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