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[[Image:1qal.png|left|200px]]


{{STRUCTURE_1qal|  PDB=1qal  |  SCENE=  }}
==THE ACTIVE SITE BASE CONTROLS COFACTOR REACTIVITY IN ESCHERICHIA COLI AMINE OXIDASE : X-RAY CRYSTALLOGRAPHIC STUDIES WITH MUTATIONAL VARIANTS==
 
<StructureSection load='1qal' size='340' side='right'caption='[[1qal]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
===THE ACTIVE SITE BASE CONTROLS COFACTOR REACTIVITY IN ESCHERICHIA COLI AMINE OXIDASE : X-RAY CRYSTALLOGRAPHIC STUDIES WITH MUTATIONAL VARIANTS===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1qal]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QAL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QAL FirstGlance]. <br>
{{ABSTRACT_PUBMED_10387067}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=TPQ:5-(2-CARBOXY-2-AMINOETHYL)-2-HYDROXY-1,4-BENZOQUINONE'>TPQ</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qal OCA], [https://pdbe.org/1qal PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qal RCSB], [https://www.ebi.ac.uk/pdbsum/1qal PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qal ProSAT]</span></td></tr>
[[1qal]] is a 2 chain structure of [[Copper Amine Oxidase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QAL OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/AMO_ECOLI AMO_ECOLI] The enzyme prefers aromatic over aliphatic amines.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qa/1qal_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qal ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Copper Amine Oxidase|Copper Amine Oxidase]]
*[[Copper amine oxidase 3D structures|Copper amine oxidase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:010387067</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Monoamine oxidase]]
[[Category: Large Structures]]
[[Category: Jaeger, J.]]
[[Category: Jaeger J]]
[[Category: Knowles, P F.]]
[[Category: Knowles PF]]
[[Category: McPherson, M J.]]
[[Category: McPherson MJ]]
[[Category: Murray, J M.]]
[[Category: Murray JM]]
[[Category: Phillips, S E.]]
[[Category: Phillips SE]]
[[Category: Saysell, C G.]]
[[Category: Saysell CG]]
[[Category: Wilmot, C M.]]
[[Category: Wilmot CM]]
[[Category: Mushroom shaped homodimer with mainly beta structure. there are 3 small peripheral alpha/beta domains.]]
[[Category: Oxidoreductase]]

Latest revision as of 09:02, 17 April 2024

THE ACTIVE SITE BASE CONTROLS COFACTOR REACTIVITY IN ESCHERICHIA COLI AMINE OXIDASE : X-RAY CRYSTALLOGRAPHIC STUDIES WITH MUTATIONAL VARIANTSTHE ACTIVE SITE BASE CONTROLS COFACTOR REACTIVITY IN ESCHERICHIA COLI AMINE OXIDASE : X-RAY CRYSTALLOGRAPHIC STUDIES WITH MUTATIONAL VARIANTS

Structural highlights

1qal is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

AMO_ECOLI The enzyme prefers aromatic over aliphatic amines.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1qal, resolution 2.20Å

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