1pko: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
New page: left|200px<br /><applet load="1pko" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pko, resolution 1.45Å" /> '''Myelin Oligodendrocy...
 
No edit summary
 
(13 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1pko.jpg|left|200px]]<br /><applet load="1pko" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1pko, resolution 1.45&Aring;" />
'''Myelin Oligodendrocyte Glycoprotein (MOG)'''<br />


==Overview==
==Myelin Oligodendrocyte Glycoprotein (MOG)==
Multiple sclerosis is a chronic disease of the central nervous system, (CNS) characterized by inflammation, demyelination, and axonal loss. The, immunopathogenesis of demyelination in multiple sclerosis involves an, autoantibody response to myelin oligodendrocyte glycoprotein (MOG), a type, I transmembrane protein located at the surface of CNS myelin. Here we, present the crystal structures of the extracellular domain of MOG (MOGIgd), at 1.45-A resolution and the complex of MOGIgd with the antigen-binding, fragment (Fab) of the MOG-specific demyelinating monoclonal antibody, 8-18C5 at 3.0-A resolution. MOGIgd adopts an IgV like fold with the, A'GFCC'C" sheet harboring a cavity similar to the one used by the, costimulatory molecule B7-2 to bind its ligand CTLA4. The antibody 8-18C5, binds to three loops located at the membrane-distal side of MOG with a, surprisingly dominant contribution made by MOG residues 101-108 containing, a strained loop that forms the upper edge of the putative ligand binding, site. The sequence R101DHSYQEE108 is unique for MOG, whereas large parts, of the remaining sequence are conserved in potentially tolerogenic MOG, homologues expressed outside the immuno-privileged environment of the CNS., Strikingly, the only sequence identical to DHSYQEE was found in a, Chlamydia trachomatis protein of unknown function, raising the possibility, that Chlamydia infections may play a role in the MOG-specific autoimmune, response in man. Our data provide the structural basis for the development, of diagnostic and therapeutic strategies targeting the pathogenic, autoantibody response to MOG.
<StructureSection load='1pko' size='340' side='right'caption='[[1pko]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1pko]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PKO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PKO FirstGlance]. <br>
1PKO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1PKO OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pko OCA], [https://pdbe.org/1pko PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pko RCSB], [https://www.ebi.ac.uk/pdbsum/1pko PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pko ProSAT]</span></td></tr>
Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein., Breithaupt C, Schubart A, Zander H, Skerra A, Huber R, Linington C, Jacob U, Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9446-51. Epub 2003 Jul 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12874380 12874380]
</table>
== Function ==
[https://www.uniprot.org/uniprot/MOG_RAT MOG_RAT] Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pk/1pko_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pko ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Breithaupt C]]
[[Category: Breithaupt, C.]]
[[Category: Huber R]]
[[Category: Huber, R.]]
[[Category: Jacob U]]
[[Category: Jacob, U.]]
[[Category: Linington C]]
[[Category: Linington, C.]]
[[Category: Schubart A]]
[[Category: Schubart, A.]]
[[Category: Skerra A]]
[[Category: Skerra, A.]]
[[Category: Zander H]]
[[Category: Zander, H.]]
[[Category: igv-domain]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 23:53:45 2007''

Latest revision as of 08:56, 17 April 2024

Myelin Oligodendrocyte Glycoprotein (MOG)Myelin Oligodendrocyte Glycoprotein (MOG)

Structural highlights

1pko is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.45Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MOG_RAT Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1pko, resolution 1.45Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=1pko&oldid=4129388"