1olz: Difference between revisions
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==The ligand-binding face of the semaphorins revealed by the high resolution crystal structure of SEMA4D== | |||
<StructureSection load='1olz' size='340' side='right'caption='[[1olz]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
=== | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1olz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OLZ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1olz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1olz OCA], [https://pdbe.org/1olz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1olz RCSB], [https://www.ebi.ac.uk/pdbsum/1olz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1olz ProSAT]</span></td></tr> | |||
== | </table> | ||
[[1olz]] is a 2 chain structure with sequence from [ | == Function == | ||
[https://www.uniprot.org/uniprot/SEM4D_HUMAN SEM4D_HUMAN] Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.<ref>PMID:16055703</ref> <ref>PMID:19788569</ref> <ref>PMID:20877282</ref> <ref>PMID:8876214</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ol/1olz_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1olz ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Semaphorin|Semaphorin]] | *[[Semaphorin 3D structures|Semaphorin 3D structures]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Davis | [[Category: Large Structures]] | ||
[[Category: Esnouf | [[Category: Davis SJ]] | ||
[[Category: Harlos | [[Category: Esnouf RM]] | ||
[[Category: Jones | [[Category: Harlos K]] | ||
[[Category: Love | [[Category: Jones EY]] | ||
[[Category: Mavaddat | [[Category: Love CA]] | ||
[[Category: Stuart | [[Category: Mavaddat N]] | ||
[[Category: Stuart DI]] | |||