Cefotaxime: Difference between revisions

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Alexander Berchansky

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 <StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='10/1042557/Cv/1'>
-Cefotaxime is an antibiotic used to treat a number of bacterial infections in human, other animals and plant tissue culture. Specifically in humans it is used to treat joint infections, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, sepsis, gonorrhea, and cellulitis.<ref name="a3">[https://www.drugs.com/monograph/cefotaxime.html "Cefotaxime Sodium".] The American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 8 December 2016.</ref> See also [https://en.wikipedia.org/wiki/Cefotaxime Cefotaxime].
+Cefotaxime is [[cephalosporin]] antibiotic used to treat a number of bacterial infections in human, other animals and plant tissue culture. Specifically in humans it is used to treat joint infections, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, sepsis, gonorrhea, and cellulitis.<ref name="a3">[https://www.drugs.com/monograph/cefotaxime.html "Cefotaxime Sodium".] The American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 8 December 2016.</ref> See also [https://en.wikipedia.org/wiki/Cefotaxime Cefotaxime].
+Cefotaxime is a [[Beta-lactam antibiotics|β-lactam antibiotic]] (which refers to the structural components of the drug molecule itself). As a class, β-lactams inhibit bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs). This inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) in the absence of cell wall assembly.<ref name="a9">[https://web.archive.org/web/20070915143604/http://www.merck.com/mmpe/lexicomp/cefotaxime.html "Cefotaxime".] Drug Information Provided by Lexi-Comp. Archived from the original on 15 September 2007 – via Merck Manuals Professional Edition.</ref>
 <scene name='10/1042557/Cv/2'>Penicillin-Binding Protein 1A with Cefotaxime</scene> ([[2c5w]]).
+<scene name='10/1042557/Cv/4'>Cefotaxime binding site</scene>.
 </StructureSection>
 == References ==
 <references/>