Urokinase receptor: Difference between revisions
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<StructureSection load='2i9b' size='340' side='right' caption='Human uPAR (grey) complex with glycosylated uPA (magenta) and sulfate (PDB code [[2i9b]])' scene=''> | <StructureSection load='2i9b' size='340' side='right' caption='Human uPAR (grey) complex with glycosylated uPA (magenta) and sulfate (PDB code [[2i9b]])' scene='10/1041521/Cv/1'> | ||
== Function == | == Function == | ||
'''Urokinase receptor''' or '''Urokinase plasminogen activator surface receptor''' or '''CD87''' (uPAR) plays an important role in migration of T cells<ref>PMID:8283034</ref>. uPAR is a GPI-anchored membrane protein. It triggers cell signalling and regulates gene expression within the cell. | '''Urokinase receptor''' or '''Urokinase plasminogen activator surface receptor''' or '''CD87''' (uPAR) plays an important role in migration of T cells<ref>PMID:8283034</ref>. uPAR is a GPI-anchored membrane protein. It triggers cell signalling and regulates gene expression within the cell. The invasive potential of uPAR expressing tumor cells is modulated by interaction with | ||
urokinase plasminogen activator (uPA)<ref>PMID:1659573</ref>. | |||
== Disease == | == Disease == | ||
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==Structural highlights== | ==Structural highlights== | ||
The binding of uPAR and urokinase-type plasminogen activator (uPA) is mediated by hydrophobic numerous interactions. In particular the interactions between uPA residue Trp30 and uPAR numerous hydrophobic residues<ref>PMID:16979660</ref>. | The binding of uPAR and urokinase-type plasminogen activator (uPA) is mediated by hydrophobic numerous interactions. <scene name='10/1041521/Cv/2'>In particular the interactions between uPA residue Trp30 and uPAR numerous hydrophobic residues</scene><ref>PMID:16979660</ref>. | ||
==3D structures of urokinase receptor== | ==3D structures of urokinase receptor== | ||